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A monoclonal antibody is secreted by a single B lymphocyte clone which can only produce a kind of proprietary antibody against an antigen-determining cluster, and has the characteristics of single biological activity and particular specificity of binding with antigen.

The active sites of monoclonal antibody drugs involve a variety of tumor-related signaling pathways and targets. For example, the most common targets are epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor -2 (her-2 /neu, or egfr-2). Besides, there is a group of targets that are getting a lot of attention called “immune checkpoints”.

After the activation of immune cells that regulate the anti-tumor immune response, a variety of highly expressed receptors on the surface of immune cells bind to the highly expressed ligands on the surface of tumor cells to reduce the strength of the immune response, thus down-regulating the intensity of tumor-related immune response. These immunoregulatory sites are known as immune checkpoints. Currently, the most widely studied immune checkpoints are PD-1, PD-L1, and CTLA-4.

Targetmol provides 30 monoclonal antibody drugs, including the above immune checkpoint inhibitors and other types of targeted antibody inhibitors, for scientific research only.

Cat. No. 製品名 CAS No. Purity Chemical Structure
T9962 Mepolizumab 196078-29-2 98%
Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophili...
T37445 Etanercept 185243-69-0 98%
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β ...
T9905 Cetuximab 205923-56-4 98%
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, ...
T9925 Ofatumumab 679818-59-8 98%
Ofatumumab
Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation
T12177 Natalizumab 189261-10-7 98%
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
T35392 Tiragolumab 1918185-84-8 98%
Tiragolumab(MTIG-7192A) is a monoclonal antibody that targets T-cell immunoglobulin and the ITIM structural domain (TIGIT).Tiragolumab is often used in combinati...
T77477 Polatuzumab 2279068-37-8 98%
Polatuzumab is a monoclonal antibody that targets CD79b and carries chemotherapeutically active molecules.Polatuzumab adheres to CD79b proteins and transports th...
T77471 Tinurilimab 2226224-30-0 98%
Tinurilimab
Tinurilimab (Bay 1834942) is a monoclonal antibody that targets and inhibits CEACAM6, an immune checkpoint regulator. Tinurilimab can be used in studies about ef...
T77466 Tremelimumab 745013-59-6 98%
Tremelimumab is a cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blocking antibody.Tremelimumab is often used in combination with Durvalumab for the treatm...
T77457 Emicizumab 1610943-06-0 98%
Emicizumab(ACE 910) is a humanized monoclonal antibody that bridges activated factor IX and activated factor X to mimic the function of activated factor VIII. Em...
T77456 Lumiliximab 357613-86-6 98%
Lumiliximab
Lumiliximab (IDEC-152) is a primate-ized chimeric antibody targeting CD23 rhesus monkey/human chimeric antibody with inhibitory effects on IgE antibody productio...
T77455 Burosumab 1610833-03-8 98%
Burosumab(KRN23) is a human monoclonal antibody targeting fibroblast growth factor 23 (FGF23) for the treatment of cutaneous-skeletal hypophosphatemic syndrome (...
T77445 Apitegromab 2278276-46-1 98%
Apitegromab
Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal...
T77440 Codrituzumab 1365267-33-9 98%
Codrituzumab
Codrituzumab (GC3) is a humanized antibody against the glypican-3 hepatocellular carcinoma protein that can be used in combination with sorafenib to study incura...
T77439 Glembatumumab 1020264-78-1 98%
Glembatumumab
Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma.Glem...
T77437 Telisotuzumab 1781223-80-0 98%
Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisot...
T77422 Lacutamab 2187368-16-5 98%
Lacutamab
Lacutamab (IPH 4102) is a potent and selective humanized anti-KIR3DL2 antibody.Lacutamab has potential anticancer activity for the study of leukemia and lymphoma...
T77407 Ensituximab 1092658-06-4 98%
Ensituximab
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic ...
T77399 Crizanlizumab 1690318-25-2 98%
Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.
T77385 Idactamab 2245205-37-0 98%
Idactamab
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
Mepolizumab
T9962
Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophili...
Etanercept
T37445
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β ...
Cetuximab
T9905
Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, ...
Ofatumumab
T9925
Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation
Natalizumab
T12177
Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
Tiragolumab
T35392
Tiragolumab(MTIG-7192A) is a monoclonal antibody that targets T-cell immunoglobulin and the ITIM structural domain (TIGIT).Tiragolumab is often used in combinati...
Polatuzumab
T77477
Polatuzumab is a monoclonal antibody that targets CD79b and carries chemotherapeutically active molecules.Polatuzumab adheres to CD79b proteins and transports th...
Tinurilimab
T77471
Tinurilimab (Bay 1834942) is a monoclonal antibody that targets and inhibits CEACAM6, an immune checkpoint regulator. Tinurilimab can be used in studies about ef...
Tremelimumab
T77466
Tremelimumab is a cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blocking antibody.Tremelimumab is often used in combination with Durvalumab for the treatm...
Emicizumab
T77457
Emicizumab(ACE 910) is a humanized monoclonal antibody that bridges activated factor IX and activated factor X to mimic the function of activated factor VIII. Em...
Lumiliximab
T77456
Lumiliximab (IDEC-152) is a primate-ized chimeric antibody targeting CD23 rhesus monkey/human chimeric antibody with inhibitory effects on IgE antibody productio...
Burosumab
T77455
Burosumab(KRN23) is a human monoclonal antibody targeting fibroblast growth factor 23 (FGF23) for the treatment of cutaneous-skeletal hypophosphatemic syndrome (...
Apitegromab
T77445
Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal...
Codrituzumab
T77440
Codrituzumab (GC3) is a humanized antibody against the glypican-3 hepatocellular carcinoma protein that can be used in combination with sorafenib to study incura...
Glembatumumab
T77439
Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma.Glem...
Telisotuzumab
T77437
Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisot...
Lacutamab
T77422
Lacutamab (IPH 4102) is a potent and selective humanized anti-KIR3DL2 antibody.Lacutamab has potential anticancer activity for the study of leukemia and lymphoma...
Ensituximab
T77407
Ensituximab (NEO-102) is a quasi-selective IgG1 monoclonal antibody against the MUC5AC variant with anti-tumour activity that inhibits colorectal and pancreatic ...
Crizanlizumab
T77399
Crizanlizumab (Adakveo) is a humanized monoclonal antibody against P-selectin for the prevention of pain crises in sickle cell disease.
Idactamab
T77385
Idactamab (INT-001) is a monoclonal antibody to the human amino acid transport protein ASCT2.
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