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Anti-Breast Cancer Compound Library

カタログ番号 L2191
  ライブラリー構成化合物リスト   Excel SDF

Breast cancer is an uncontrolled growth of breast cells. Among women, breast cancer is the second most common cancer diagnosed, after skin cancer (, and the second leading cause of cancer death, after lung cancer. In recent years, incidence rates have increased slightly (by 0.3% per year).

There are several types of breast cancer, and they are broken into two main categories: noninvasive or in situ (ductal or lobular), and invasive (ductal or lobular). In addition, breast cancer can be categorized into four molecular subtypes: a “basal-like” subgroup with low estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) and expression of basal cytokeratins (ER-PR-HER2-); a subgroup mainly driven by HER2 amplification and overexpression while being ER/PR low (ER-PR-HER2+); a luminal A group with high ER/PR and low HER2 (ER+PR+HER2-); a luminal B group with high ER/HER2 and low PR (ER+PR-HER2+). Depending on the caner’s stage and molecular type, treatment options and prognostics of breast cancers are different: a combination of surgery, radiation therapy, chemotherapy, hormone therapy and/or administration of a targeted therapy (anti-HER2) or non-HER2 targeted therapy. Several potential targets for new breast cancer drugs have been identified in recent years. Drugs based on these targets, such as kinase inhibitors (AKT), and PD-L1, are now being studied to treat triple-negative breast cancers, either by themselves, or in combination with chemotherapy.

TargetMol’s Anti-Breast Cancer Compound Library collects 1939 compounds related to breast cancer, including all reported compounds with anti-breast cancer therapeutic effect, and compounds targeting related targets in signaling pathway (HER-2, VEGF, EGFR, PARP, CDK4/6, HSP, PD-1, SET7/9, BRCA, etc.). It is a power tool for breast cancer drug discovery.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 抗乳癌治がん活性を有するまたは乳がんの主要なシグナル伝達経路を標的とする1939の化合物を独自にコレクション
  • 乳がんの創薬スクリーニング、機序研究に最適
  • 主なターゲットはHER-2、VEGF、EGFR、PARP、CDK4 / 6、HSP、PD-1、SET7 / 9、BRCAなど
  • 一部に上市品または臨床試験中の化合物を含む
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • NMRとHPLC/LCMSにより高純度と高品質を担保

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L2191)

Publications Cited TargetMol Libraries

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Apoptosis (351)
Autophagy (264)
NF-κB (227)
CDK (183)
PI3K (172)
Reactive Oxygen Species (159)
EGFR (159)
VEGFR (146)
PPAR (116)
HDAC (102)
Endogenous Metabolite (93)
Akt (93)
mTOR (90)
FGFR (75)
AMPK (73)
Antibacterial (69)
PDGFR (63)
HSP (57)
GSK-3 (57)
PARP (56)
COX (53)
TGF-beta/Smad (51)
FLT (44)
ERK (43)
c-Kit (43)
IκB/IKK (40)
Src (38)
DNA-PK (37)
p38 MAPK (32)
Parasite (32)
TNF (31)
S6 Kinase (30)
DNA/RNA Synthesis (30)
HER (29)
Ferroptosis (27)
STAT (27)
c-Met/HGFR (25)
JNK (25)
HIV Protease (24)
Aurora Kinase (24)
ATM/ATR (23)
Estrogen/progestogen Receptor (23)
RIP kinase (23)
NOD (23)
Mitophagy (23)
PKC (22)
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5-HT Receptor (4)
Androgen Receptor (4)
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化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE