Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

カタログ番号	製品名 / Synonyms	Species	Expression System
TMPY-05641	B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated B7-H3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPY-05641	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-05579	PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293
TMPY-05579	Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin su...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated CD47 Protein, Human, Recombinant, Biotinylated	Human	HEK293
TMPY-05191	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-03540	CD73 Protein, Rat, Recombinant (His) CD73 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03540	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-01851	CD73 Protein, Human, Recombinant (His) CD73 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01851	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPJ-00211	CD47 Protein, Human, Recombinant (His) CD47 Protein, Human, Recombinant (His)	Human	Human Cells
TMPJ-00211	CD47(Integrin-Associated Protein,IAP) is a 40 ‑ 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 b...
TMPY-03377	CD73 Protein, Cynomolgus, Recombinant (His) CD73 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-03377	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-04342	PD-1 Protein, Canine, Recombinant (His) PD-1 Protein, Canine, Recombinant (His)	Canine	HEK293
TMPY-04342	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-05079	PD-1 Protein, Human, Recombinant (mFc) PD-1 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-05079	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-05092	LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His) LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His)	Cynomolgus	HEK293
TMPY-05092	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte acti...
TMPY-01342	CD73 Protein, Mouse, Recombinant (His) CD73 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01342	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol...
TMPY-05345	TIGIT Protein, Cynomolgus, Recombinant (hFc) TIGIT Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-05345	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface...
TMPY-04989	Galectin-9 Protein, Human, Recombinant (hFc) Galectin-9 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-04989	LGALS9 (Galectin 9) is a Protein Coding gene. 6 alternatively spliced human isoforms have been reported. The galectins are a family of beta-galactoside-binding p...
TMPY-05827	PD-L2 Protein, Human, Recombinant (mFc) PD-L2 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-05827	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and ...
TMPY-05343	CD47 Protein, Cynomolgus, Rhesus, Recombinant (His) CD47 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-05343	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-01621	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01621	Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on ...
TMPY-00130	VISTA Protein, Mouse, Recombinant (hFc) VISTA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-00130	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It...
TMPY-02011	CD96 Protein, Human, Recombinant (His) CD96 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-02011	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-04970	TIGIT Protein, Human, Recombinant (hFc) TIGIT Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-04970	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface...
TMPY-05208	PD-L1 Protein, Human, Recombinant PD-L1 Protein, Human, Recombinant	Human	HEK293
TMPY-05208	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...