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Epigenetics Compound Library

カタログ番号 L1200
  ライブラリー構成化合物リスト   Excel SDF

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence. Epigenetics has the potential to be a key element in a paradigm change of our understanding of aging, development, cancer, heart disease, psychological disorders, and other diseases. For example, Epigenetic modifications have a considerable effect on cancer. Changes in the pattern of histone modifications in the promoter sequences as epigenetic regulation lead to changes in chromatin structure thus may be the cause of altered gene expression by activation of oncogenes.

The Epigenetics Compound Library by TargetMol, containing 953 compounds related to epigenetic regulation, can be used for research in epigenetics, high throughput screening and high content screening for new drugs in epigenetic modification.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • エピジェネティクスに関連する953種類の化合物を独自に厳選したライブラリーで、新薬探索のハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • ターゲットにはHDAC、SIRT、HAT、HMTなど
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1200)

Publications Cited TargetMol Libraries

1. Neuro-oncology. 2023: noad222. 2. Protein & Cell. 2022. 3. Science Advances. 2022, 8(31): eabm3976. 4. Cancer Research. 2024. 5. Theranostics. 2021, 11(5): 2058.. 6. Oncoimmunology. 2022, 11(1): 2016158. 7. Stem Cells Translational Medicine. 2022. 8. Acta Pharmacologica Sinica. 2021: 1-13. 9. Frontiers in Oncology. 2022, 12: 870229..
10. Life Sciences. 2022: 120643. 11. Antimicrobial Agents and Chemotherapy. 2020. 12. The Journal of Immunology. 2023. 13. ACS Omega. 2021. 14. Oncology. 2022, 12: 870229. 15. bioRxiv. 2023: 2023.01. 31.526483. 16. Cell Stem Cell. 2022 Apr 29(4) 545–558. 17. Science Bulletin. 2022. 18. Science Translational Medicine. 2022, 14(656): eabn3231. 19. Science Advances. 2023, 9(9): eade3760. 20. Nature. 2020, 582: 289-293. 21. Nature Biotechnology. 2021, 39(11): 1444-1452. 22. Nature Communications. 2022, 13(1): 1-15.. 23. Nature Communications. 2023, 14(1): 1020.. 24. Nature Communications. 2023, 14(1): 2756.. 25. Blood. 2021, 137(11): 1478-1490. 26. Nucleic Acids Research. 2021. 27. Nature Communications. 2023, 14(1): 7574. 28. Advanced Science. 2020, 7(16): 2000925. 29. Angewandte Chemie. 2021. 30. Acta Pharmaceutica Sinica B. 2022. 31. Protein & Cell. 2021, 12(11): 877-888. 32. Bone Research. 2023, 11(1): 54. 33. Pharmacology & Therapeutics. (2021): 107930. 34. Nature Communications. 2021, 12(1): 1-12. 35. Journal of Cell Biology. 2022, 221(5): e202112024. 36. Zhu M, Han Y, Gu T, et al.Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway.Cell Reports.2024, 43(4). 37. Cai J, Zhou J, Meng Z, et al.Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR.Acta Pharmacologica Sinica.2024: 1-12. 38. Sui Y, Wang T, Mei Y, et al.Targeting Super-Enhancer-Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor Resistance.Cancer Research.2024 39. Wang Z, Zhang X, Luo Y, et al.Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis).Cell Death & Disease.2024, 15(5): 375.
隠し

ライブラリーの構成

Apoptosis (154)
Epigenetic Reader Domain (144)
Histone Methyltransferase (117)
HDAC (107)
Autophagy (100)
JAK (98)
PKC (78)
AMPK (77)
PARP (75)
Sirtuin (58)
Aurora Kinase (53)
HIF/HIF Prolyl-Hydroxylase (48)
HIF (36)
Histone Demethylase (36)
Histone Acetyltransferase (28)
Tyrosine Kinases (27)
CDK (27)
Endogenous Metabolite (24)
FLT (24)
DNA Methyltransferase (23)
Antibacterial (22)
Pim (21)
STAT (20)
HIV Protease (18)
Influenza Virus (16)
PKA (16)
Akt (16)
VEGFR (15)
Src (15)
Mitophagy (15)
Parasite (13)
Caspase (13)
Antibiotic (13)
EGFR (13)
Wnt/beta-catenin (12)
ERK (12)
FGFR (10)
NF-κB (10)
PDGFR (10)
BCL (10)
Reactive Oxygen Species (10)
COX (9)
PPAR (9)
Bcr-Abl (9)
Virus Protease (9)
p38 MAPK (9)
Topoisomerase (8)
Syk (8)
ROCK (8)
c-RET (8)
TNF (7)
PI3K (7)
MEK (7)
Casein Kinase (7)
PAD (7)
P450 (7)
GSK-3 (7)
DNA/RNA Synthesis (7)
PLK (6)
JNK (6)
Antifungal (6)
IL Receptor (6)
Dehydrogenase (5)
CaMK (5)
Adenosine Receptor (5)
AChR (5)
PDE (5)
Ferroptosis (5)
Serine/threonin kinase (5)
Nrf2 (5)
S6 Kinase (5)
Calcium Channel (5)
Methionine Adenosyltransferase (MAT) (5)
p53 (4)
MAO (4)
Chk (4)
IκB/IKK (4)
HSV (4)
NO Synthase (4)
mTOR (3)
HER (3)
IGF-1R (3)
IFNAR (3)
MMP (3)
Nucleoside Antimetabolite/Analog (3)
Histamine Receptor (3)
Monoamine Oxidase (3)
RAAS (3)
GABA Receptor (3)
BTK (3)
Trk receptor (3)
c-Fms (3)
SGK (3)
Potassium Channel (3)
DYRK (3)
MAPK (3)
HBV (3)
AChE (2)
ATP Citrate Lyase (2)
Ligand for E3 Ligase (2)
MLK (2)
TLR (2)
TGF-beta/Smad (2)
PROTACs (2)
Dopamine Receptor (2)
Hippo pathway (2)
Indoleamine 2,3-Dioxygenase (IDO) (2)
Antiviral (2)
Myosin (2)
HCV Protease (2)
cholecystokinin (2)
Carboxypeptidase (2)
c-Kit (2)
Gamma-secretase (2)
LDL (2)
Microtubule Associated (2)
transporter (2)
Tyrosinase (2)
Fatty Acid Synthase (2)
DUB (2)
YAP (2)
DNA Alkylation (2)
Ligands for Target Protein for PROTAC (2)
Sodium Channel (2)
Serine Protease (2)
5-HT Receptor (2)
Integrin (2)
Phosphatase (2)
Anti-infection (2)
Proteasome (1)
Reverse Transcriptase (1)
Phospholipase (1)
Cannabinoid Receptor (1)
DAPK (1)
NOD (1)
NADPH-oxidase (1)
BMI-1 (1)
TAM Receptor (1)
CFTR (1)
PD-1/PD-L1 (1)
Beta Amyloid (1)
PTEN (1)
GST (1)
NADPH (1)
SIK (1)
IAP (1)
Adrenergic Receptor (1)
Glucokinase (1)
Antifolate (1)
Estrogen Receptor/ERR (1)
c-Myc (1)
Tie-2 (1)
PERK (1)
BACE (1)
UGT (1)
Antioxidant (1)
c-Met/HGFR (1)
Estrogen/progestogen Receptor (1)
DNA-PK (1)
NPC1L1 (1)
Transferase (1)
Carbonic Anhydrase (1)
NOS (1)
Proton pump (1)
Chloride channel (1)
E1/E2/E3 Enzyme (1)
GRK (1)
Free radical scavengers (1)
Lipoxygenase (1)
LRRK2 (1)
SARS-CoV (1)
HSP (1)
P-gp (1)
Beta-Secretase (1)
SGLT (1)
Telomerase (1)
Interleukin (1)
Androgen Receptor (1)
GluR (1)
Raf (1)
Mdm2 (1)
CCR (1)
Hedgehog/Smoothened (1)
Guanylate cyclase (1)
ROS (1)
Antifection (1)
Mitochondrial Metabolism (1)
DNA gyrase (1)
NMDAR (1)
P2X Receptor (1)
S1P Receptor (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE