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Ferroptosis Compound Library

カタログ番号 L8700
  ライブラリー構成化合物リスト   Excel SDF

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically, biochemically and morphologically distinct from other forms of regulated cell death such as apoptosis, necroptosis, and autophagic cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Understanding the molecular mechanisms and signaling pathways of ferroptosis may provide new diagnostic and therapeutic approaches to regulate cell survival and death in human disease.

TargetMol collects 779 compounds related to ferroptosis signaling pathway with targets including GPX4, System Xc−, HSPB1, NRF2, VDAC2/3, Ras, TFR1, NOX, p53, CARS, ROS, SLC7A11, etc. Iron chelators and lipid peroxidation inhibitors are also included in this library.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • フェロトーシスシグナル伝達経路を標的とする779化合物を収集した独自のライブラリーで、新規創薬ターゲットの同定、薬剤探索および機序研究に最適
  • ターゲットにはGPX4、ROS、p53、Nrf2など
  • 一部の化合物はFDA承認済み
  • 化合物の概要、化学構造、標的、生物活性など詳細な情報を提供
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L8700)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Apoptosis (166)
Autophagy (126)
Endogenous Metabolite (120)
Reactive Oxygen Species (110)
Ferroptosis (91)
Antioxidant (86)
Antibacterial (73)
NF-κB (60)
ROS (38)
Nrf2 (32)
COX (30)
Antifungal (29)
Ras (25)
p53 (23)
Influenza Virus (22)
Raf (21)
P450 (19)
PPAR (19)
Parasite (19)
Antibiotic (19)
Lipoxygenase (18)
HIV Protease (18)
p38 MAPK (17)
ERK (16)
TNF (16)
Calcium Channel (15)
Mitophagy (15)
Virus Protease (14)
Dehydrogenase (14)
MEK (13)
STAT (13)
Proteasome (12)
DNA/RNA Synthesis (12)
DPP-4 (11)
HMG-CoA Reductase (10)
E1/E2/E3 Enzyme (10)
Mdm2 (10)
AChE (9)
HSV (9)
AMPK (9)
5-HT Receptor (9)
MMP (9)
Estrogen/progestogen Receptor (8)
Akt (8)
Tyrosinase (8)
TRP/TRPV Channel (8)
Mitochondrial Metabolism (8)
PKC (7)
HIF/HIF Prolyl-Hydroxylase (7)
NADPH (7)
Beta Amyloid (7)
IL Receptor (7)
AChR (7)
Histamine Receptor (7)
CDK (7)
Caspase (7)
PI3K (7)
Dopamine Receptor (6)
BCL (6)
Rho (6)
Glutathione Peroxidase (6)
EGFR (6)
Xanthine Oxidase (6)
Wnt/beta-catenin (6)
Interleukin (6)
Sirtuin (6)
MAO (5)
iGluR (5)
JNK (5)
P-gp (5)
Reverse Transcriptase (5)
IκB/IKK (5)
SARS-CoV (5)
HIF (5)
RAAS (5)
Estrogen Receptor/ERR (5)
HBV (5)
PARP (5)
Potassium Channel (4)
FGFR (4)
Glucosidase (4)
NO Synthase (4)
PDGFR (4)
ROS Kinase (4)
ATPase (4)
VEGFR (4)
NOS (4)
TLR (4)
Trk receptor (4)
Topoisomerase (4)
BACE (4)
Phospholipase (3)
HDAC (3)
GPX (3)
GABA Receptor (3)
mTOR (3)
ALK (3)
Free radical scavengers (3)
Aurora Kinase (3)
HSP (3)
Epigenetic Reader Domain (3)
MAPK (3)
TGF-beta/Smad (3)
transporter (3)
Gamma-secretase (3)
Aromatase (3)
NADPH-oxidase (3)
Reductase (3)
DNA Alkylator/Crosslinker (3)
PKA (3)
PDE (3)
Adrenergic Receptor (3)
S6 Kinase (3)
AhR (3)
Src (3)
Sodium Channel (3)
HCV Protease (3)
NOD-like Receptor (NLR) (3)
Carbonic Anhydrase (3)
Aryl Hydrocarbon Receptor (3)
Phosphatase (2)
Serine Protease (2)
cell cycle arrest (2)
GSK-3 (2)
Prostaglandin Receptor (2)
c-Met/HGFR (2)
Histone Acetyltransferase (2)
GTPase (2)
Adenosine Receptor (2)
JAK (2)
RSV (2)
Amino Acids and Derivatives (2)
ROR (2)
Transferase (2)
PKM (2)
Cysteine Protease (2)
Antiviral (2)
Liver X Receptor (2)
Glucocorticoid Receptor (2)
Opioid Receptor (2)
FLT (2)
c-Kit (2)
Anti-infection (2)
GluR (2)
NOD (2)
IGF-1R (2)
CaMK (2)
UGT (2)
Telomerase (2)
Glucokinase (2)
SGLT (2)
IAP (2)
Beta-Secretase (2)
IRAK (1)
Syk (1)
Platelet aggregation (1)
Monoamine Oxidase (1)
Imidazoline Receptor (1)
lysosomal autophagy (1)
CFTR (1)
PLK (1)
Sigma receptor (1)
Hydroxylase (1)
c-RET (1)
Microtubule Associated (1)
DNA Methyltransferase (1)
BMI-1 (1)
Adenosine deaminase (1)
Cannabinoid Receptor (1)
Thyroid hormone receptor(THR) (1)
GPR (1)
Serine/threonin kinase (1)
RIP kinase (1)
Annexin A (1)
Immunology/Inflammation related (1)
Amylase (1)
ROCK (1)
RANKL/RANK (1)
Glutaminase (1)
FXR (1)
Nucleoside Antimetabolite/Analog (1)
Tyrosine Kinases (1)
Phosphorylase (1)
Melatonin Receptor (1)
MyD88 (1)
Dynamin (1)
Hydrogenase (1)
stilbene oxidase (1)
NPC1L1 (1)
Proton pump (1)
Chloride channel (1)
advanced glycation end products (1)
Drug Metabolite (1)
P2X Receptor (1)
ribosome (1)
Lipid (1)
c-Fms (1)
Retinoid Receptor (1)
ATM/ATR (1)
GST (1)
Casein Kinase (1)
Pyroptosis (1)
ASK (1)
LRRK2 (1)
STING (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
NMDAR (1)
DUB (1)
Somatostatin (1)
PTEN (1)
Hedgehog/Smoothened (1)
DNA Alkylation (1)
Thioredoxin (1)
Hexokinase (1)
Antifection (1)
DNA gyrase (1)
CXCR (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE