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Kinase Inhibitor Library

カタログ番号 L1600
  ライブラリー構成化合物リスト   Excel SDF

In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules (ATP) to specific substrates. This process is known as phosphorylation. The protein kinases make up the majority of all kinases and are widely studied. A protein kinase modifies other molecules, mostly proteins, by phosphorylation to regulate the majority of cellular pathways, especially those involved in signal transduction. Various other kinases act on small molecules such as lipids, carbohydrates, amino acids, and nucleotides, either for signaling or to prime them for metabolic pathways.

TargetMol’s Kinase Inhibitor Library, containing 2720 kinase inhibitors/regulators , can be used for research in chemical genomics, pharmacological study, and drug screening for related diseases.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • 2720種類のキナーゼ阻害剤を独自に収集したライブラリーで、キナーゼが関連する疾患気研究および創薬のハイスループットスクリーニング(HTS)やハイコンテンツスクリーニング(HCS)に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、一部に承認薬を含む
  • ターゲットにはMAPK、PI3K、JAK、STAT、CDK、MEK、インスリン/IGF受容体、CaMK II、PKA、JNK、PKC、RAF、EGFR、SAPK、GSK、MLCK、Srcファミリー、IKK、PDGFR、VEGFRなど
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1600)

Publications Cited TargetMol Libraries

1. Cancer Cell. 2019, 35(1): 125-139. e9. 2. Journal of Experimental & Clinical Cancer Research. 2023, 42(1): 1-22.. 3. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2023: 189021. 4. Frontiers in Cell and Developmental Biology. 2022.1. 5. International Journal of Molecular Sciences. 2022, 23(3): 1906. 6. International Journal of Molecular Sciences. 2022, 23(2): 776. 7. International Journal of Molecular Sciences. 2019, 20(22): 5780. 8. bioRxiv. 2023: 2023.06. 22.546046.. 9. Cell Stem Cell. 2022 Apr 29(4) 545–558.
隠し

ライブラリーの構成

Apoptosis (385)
Autophagy (292)
CDK (232)
PI3K (201)
EGFR (191)
VEGFR (160)
mTOR (112)
JAK (111)
ERK (104)
Akt (104)
p38 MAPK (102)
FLT (101)
Src (100)
PDGFR (92)
PKC (88)
AMPK (84)
GSK-3 (83)
FGFR (83)
Raf (81)
c-Kit (75)
Ras (74)
NF-κB (71)
c-Met/HGFR (69)
Bcr-Abl (66)
ALK (58)
Aurora Kinase (57)
MAPK (57)
BTK (55)
JNK (52)
PKA (49)
MEK (49)
Tyrosine Kinases (48)
ROCK (48)
Casein Kinase (47)
Endogenous Metabolite (41)
Serine/threonin kinase (41)
IGF-1R (40)
Antibacterial (40)
c-RET (38)
TAM Receptor (38)
DNA-PK (38)
Epigenetic Reader Domain (36)
CaMK (34)
Trk receptor (34)
IκB/IKK (34)
Glucosidase (34)
FAK (33)
S6 Kinase (32)
TGF-beta/Smad (31)
PLK (31)
RIP kinase (31)
Glucokinase (30)
ATM/ATR (30)
STAT (30)
HER (30)
TNF (28)
c-Fms (28)
Syk (28)
Parasite (27)
Chk (26)
Pim (25)
PERK (24)
ROR (23)
IRAK (22)
Caspase (21)
LRRK2 (20)
COX (20)
DYRK (20)
PDK (20)
Mitophagy (19)
Antibiotic (19)
PAK (18)
HIV Protease (18)
Influenza Virus (18)
Rho (17)
Wnt/beta-catenin (17)
PI4K (16)
Reactive Oxygen Species (16)
Tyrosinase (15)
IRE1 (15)
IL Receptor (15)
DNA/RNA Synthesis (15)
ROS Kinase (14)
Ephrin Receptor (14)
Calcium Channel (14)
Ferroptosis (14)
Phosphatase (13)
AChR (13)
BCL (12)
5-HT Receptor (12)
MMP (12)
PPAR (12)
Antifungal (12)
Adrenergic Receptor (11)
CSF-1R (11)
P450 (11)
Potassium Channel (11)
ROS (10)
MNK (10)
GRK (10)
Kinesin (10)
S1P Receptor (10)
PDE (10)
Dehydrogenase (10)
MLK (10)
Discoidin Domain Receptor (DDR) (10)
PKM (9)
SGK (9)
Microtubule Associated (9)
NO Synthase (9)
HSV (9)
Serine Protease (9)
Adenosine Receptor (9)
Wee1 (8)
SARS-CoV (8)
Sodium Channel (8)
PARP (8)
Antiviral (8)
LIM Kinase (8)
Beta Amyloid (8)
HDAC (8)
AAK1 (AP2 associated kinase 1) (7)
Tie-2 (7)
Virus Protease (7)
SIK (7)
Mitochondrial Metabolism (7)
AChE (7)
Lipoxygenase (7)
Interleukin (7)
P-gp (6)
Drug Metabolite (6)
MELK (6)
HCV Protease (6)
Topoisomerase (6)
Histamine Receptor (6)
Nrf2 (6)
Integrin (5)
LDL (5)
Hippo pathway (5)
TOPK (5)
ACK (5)
Histone Methyltransferase (5)
Ligand for E3 Ligase (5)
Antioxidant (5)
Dopamine Receptor (5)
transporter (5)
PYK2 (5)
ASK (5)
Antifection (5)
TLR (5)
Carbonic Anhydrase (4)
Estrogen/progestogen Receptor (4)
Carboxypeptidase (4)
DAPK (4)
LPL Receptor (4)
Myosin (4)
GTPase (4)
GluR (4)
TRP/TRPV Channel (3)
Transferase (3)
Sirtuin (3)
DNA Alkylation (3)
NOS (3)
MAO (3)
YAP (3)
Aryl Hydrocarbon Receptor (3)
PAI-1 (3)
Hexokinase (3)
E1/E2/E3 Enzyme (3)
Haspin Kinase (3)
ATPase (3)
p53 (3)
Hck (3)
IFNAR (3)
Glutathione Peroxidase (3)
Indoleamine 2,3-Dioxygenase (IDO) (3)
BACE (3)
Ligands for Target Protein for PROTAC (3)
NADPH (3)
HIF/HIF Prolyl-Hydroxylase (3)
Phospholipase (3)
cholecystokinin (3)
Estrogen Receptor/ERR (3)
HSP (3)
Prostaglandin Receptor (3)
HBV (3)
Reverse Transcriptase (2)
Anti-infection (2)
NADPH-oxidase (2)
Cannabinoid Receptor (2)
CRISPR/Cas9 (2)
GPR (2)
HIF (2)
PTEN (2)
RAAS (2)
DUB (2)
Chloride channel (2)
Gamma-secretase (2)
PROTACs (2)
Histone Acetyltransferase (2)
FXR (2)
Nucleoside Antimetabolite/Analog (2)
Beta-Secretase (2)
cAMP (2)
BCRP (2)
Serotonin Transporter (2)
Sigma receptor (1)
Melatonin Receptor (1)
MRP (1)
Liver X Receptor (1)
Antifolate (1)
BMI-1 (1)
cell cycle arrest (1)
NAMPT (1)
gp120/CD4 (1)
RSV (1)
Necroptosis (1)
CETP (1)
Protease-activated Receptor (1)
Fer/FerT kinase (1)
p97 (1)
Histone Demethylase (1)
RAR/RXR  (1)
Arrestin (1)
AhR (1)
MyD88 (1)
DHFR (1)
PD-1/PD-L1 (1)
NPC1L1 (1)
Proton pump (1)
Stemness kinase (1)
Phosphorylase (1)
iGluR (1)
Thrombopoietin Receptor (1)
GPX (1)
Decarboxylase (1)
Retinoid Receptor (1)
STING (1)
Porcupine (1)
Acyltransferase (1)
Protease (1)
Aromatase (1)
PGE Synthase (1)
ATP Citrate Lyase (1)
Lipid (1)
DNA (1)
Norepinephrine (1)
GABA Receptor (1)
Gap Junction Protein (1)
Hydroxylase (1)
RXFP receptor (1)
PAD (1)
FAAH (1)
Hedgehog/Smoothened (1)
Bombesin Receptor (1)
Fatty Acid Synthase (1)
PROTAC Linker (1)
Opioid Receptor (1)
Monoamine Transporter (1)
NMDAR (1)
P2X Receptor (1)
cGAS (1)
Proteasome (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE