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MAPK Inhibitor Library

カタログ番号 L1400
  ライブラリー構成化合物リスト   Excel SDF

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 365 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • MAPKシグナル伝達経路を標的とする365種類の生物活性化合物を独自に収集したライブラリーで、MAPK関連疾患の創薬に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、一部に承認薬を含む
  • ターゲットにはERK、JNK,、MEK、p38、MAPK、Raf、RSK、MNKなど
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1400)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Apoptosis (79)
ERK (78)
p38 MAPK (76)
Autophagy (70)
Raf (59)
Ras (52)
MEK (41)
JNK (39)
NF-κB (32)
MAPK (31)
S6 Kinase (25)
CDK (22)
Akt (21)
VEGFR (14)
Src (14)
Caspase (10)
Rho (10)
Endogenous Metabolite (9)
Aurora Kinase (9)
c-Kit (8)
PDGFR (8)
Ferroptosis (7)
mTOR (7)
Casein Kinase (7)
ROCK (6)
TGF-beta/Smad (6)
TNF (6)
Parasite (6)
MLK (6)
PKA (6)
c-RET (6)
GSK-3 (6)
PI3K (6)
Bcr-Abl (5)
MNK (5)
STAT (5)
BCL (5)
COX (5)
PKC (5)
AMPK (5)
Antifungal (5)
FLT (5)
Antibacterial (5)
PARP (4)
P450 (4)
TOPK (4)
ASK (4)
Trk receptor (4)
DNA/RNA Synthesis (4)
MMP (4)
SGK (4)
PERK (4)
Reactive Oxygen Species (3)
EGFR (3)
IGF-1R (3)
Serine Protease (3)
JAK (3)
FGFR (3)
LRRK2 (3)
P-gp (2)
c-Fms (2)
AChE (2)
Syk (2)
Sodium Channel (2)
Antiviral (2)
KLF (2)
Beta Amyloid (2)
FAK (2)
Influenza Virus (2)
NO Synthase (2)
Transferase (2)
DNA Alkylation (2)
Mitophagy (2)
Aryl Hydrocarbon Receptor (2)
GTPase (2)
ROS (2)
c-Met/HGFR (2)
HIF/HIF Prolyl-Hydroxylase (1)
AChR (1)
c-Myc (1)
Hydroxylase (1)
Virus Protease (1)
Kinesin (1)
PD-1/PD-L1 (1)
HCV Protease (1)
Glutathione Peroxidase (1)
Tie-2 (1)
Histamine Receptor (1)
Potassium Channel (1)
BACE (1)
Antibiotic (1)
Adenosine Receptor (1)
Antioxidant (1)
BMI-1 (1)
5-HT Receptor (1)
NADPH-oxidase (1)
IRAK (1)
Dehydrogenase (1)
Estrogen/progestogen Receptor (1)
AhR (1)
Integrin (1)
Tyrosinase (1)
Interleukin (1)
Tyrosine Kinases (1)
HBV (1)
transporter (1)
DNA (1)
Epigenetic Reader Domain (1)
Beta-Secretase (1)
PGE Synthase (1)
cAMP (1)
ACK (1)
Chk (1)
IL Receptor (1)
TLR (1)
Antifection (1)
Glucosidase (1)
Ephrin Receptor (1)
Drug Metabolite (1)
PDK (1)
Nrf2 (1)
PAI-1 (1)
ALK (1)
MELK (1)
RIP kinase (1)
Topoisomerase (1)
IκB/IKK (1)
CSF-1R (1)
GPX (1)
Adrenergic Receptor (1)
Calcium Channel (1)
Aromatase (1)
FXR (1)
Proton pump (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE