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Mitochondria-Targeted Compound Library

カタログ番号 L5300
  ライブラリー構成化合物リスト   Excel SDF

The mitochondrion is a double-membrane-bound discrete organelle found in most eukaryotic organisms, generating most of the cell's supply of adenosine triphosphate (ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

Mitochondria-Targeted Compound Library from TargetMol, a unique collection of 812 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • ミトコンドリアを標的として作用する唯一の承認薬イデベノンなどて作用する812種類の承認済みもしくは有望な化合物を独自に収集したライブラリーで、ミトコンドリア創薬研究に最適
  • ATPアーゼ、ミトコンドリア結合ヘキソキナーゼ、Bcl-2、NADPなどのミトコンドリア関連ターゲットを持つ化合物、オートファジー関連因子およびULK1阻害剤、その他有望なミトコンドリア標的化合物としてイオニダミン、パクリタキセルなど
  • 非臨床試験および臨床試験において生物活性と安全性が確認済み
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L5300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Reactive Oxygen Species (163)
Apoptosis (146)
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化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE