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Nuclear Receptor Compound Library

カタログ番号 L1510
  ライブラリー構成化合物リスト   Excel SDF

Nuclear receptors are a class of proteins, different from membrane receptors located in the cell membrane, found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors, thereby controlling the development, homeostasis, and metabolism of the organism. Over the last 15 years a growing number of nuclear receptors have been identified that coordinate genetic networks regulating lipid metabolism and energy utilization and underlie the pathogenesis of metabolic diseases, such as obesity, type II diabetes, hypertension, and cardiovascular disease.

TargetMol collects 531 reported compounds targeting nuclear receptors as Nuclear Receptor Compound Library, which can be used for research in nuclear receptor signaling and related diseases, and high throughput and high content screening for drug discovery.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 核内受容体関連シグナル伝達をターゲットとする531化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1510)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

PPAR (121)
Estrogen/progestogen Receptor (94)
Estrogen Receptor/ERR (84)
Autophagy (68)
Androgen Receptor (64)
Glucocorticoid Receptor (62)
Endogenous Metabolite (49)
Retinoid Receptor (39)
Apoptosis (31)
ROR (22)
Progesterone Receptor (21)
FXR (21)
Thyroid hormone receptor(THR) (21)
AhR (20)
Antibacterial (16)
Liver X Receptor (15)
COX (15)
Aryl Hydrocarbon Receptor (10)
P450 (10)
NF-κB (9)
Ferroptosis (8)
Reactive Oxygen Species (7)
Antifungal (6)
GPR (6)
AMPK (5)
RAR/RXR  (5)
Akt (5)
Potassium Channel (5)
Drug Metabolite (5)
Adrenergic Receptor (4)
Antibiotic (4)
Prostaglandin Receptor (4)
Influenza Virus (4)
Parasite (4)
TSH Receptor (4)
Mitophagy (4)
Annexin A (4)
MMP (4)
JNK (3)
IL Receptor (3)
Tyrosinase (3)
Lipoxygenase (3)
Reductase (3)
GPCR19 (3)
TRP/TRPV Channel (3)
ROS (2)
NO Synthase (2)
HIV Protease (2)
Smo (2)
BCL (2)
Interleukin (2)
Nrf2 (2)
transporter (2)
Sirtuin (2)
SARS-CoV (2)
p38 MAPK (2)
Aromatase (2)
TNF (2)
Glutathione Peroxidase (2)
Phosphatase (2)
Virus Protease (2)
AChR (2)
PARP (2)
Cannabinoid Receptor (2)
VEGFR (2)
GABA Receptor (2)
PDE (2)
p53 (2)
PKC (2)
STAT (1)
FLT (1)
c-Kit (1)
Ligand for E3 Ligase (1)
Phospholipase (1)
DNA Methyltransferase (1)
Complement System (1)
HER (1)
TAM Receptor (1)
HIF/HIF Prolyl-Hydroxylase (1)
Thrombin (1)
Sodium Channel (1)
Antifection (1)
DNA/RNA Synthesis (1)
Antioxidant (1)
HBV (1)
PKA (1)
MRP (1)
ABC (1)
Melatonin Receptor (1)
GSK-3 (1)
c-Met/HGFR (1)
Cysteine Protease (1)
Dehydrogenase (1)
Ligands for Target Protein for PROTAC (1)
HCV Protease (1)
Histone Methyltransferase (1)
Carbonic Anhydrase (1)
NOS (1)
Adenylyl cyclase (1)
Wnt/beta-catenin (1)
Leukotriene Receptor (1)
EGFR (1)
Glucosidase (1)
CaMK (1)
Epigenetic Reader Domain (1)
GluR (1)
Epoxide Hydrolase (1)
PAK (1)
Opioid Receptor (1)
Proteasome (1)
Phosphorylase (1)
Glucokinase (1)
Gamma-secretase (1)
LDL (1)
FLAP (1)
MAO (1)
ERK (1)
Calcium Channel (1)
Caspase (1)
S1P Receptor (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE