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TGF-beta/Smad Compound Library

カタログ番号 L4100
  ライブラリー構成化合物リスト   Excel SDF

Members of the transforming growth factor-β (TGF-β) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) expressed in mammalian tissues. TGF-β isoforms signal through three surface receptors, known as the TGF-β type I, type II, and type III receptors (TβRI, TβRII, and TβRIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-β and receptors transduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes.

TGF-beta/Smad Compound Library from TargetMol, a unique collection of 184 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • TGF-beta/Smadシグナル伝達をターゲットとする184化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L4100)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

PKC (77)
TGF-beta/Smad (58)
ROCK (44)
Apoptosis (22)
Autophagy (18)
ALK (18)
PKA (16)
ERK (8)
CDK (8)
Antibacterial (7)
Src (6)
Akt (6)
S6 Kinase (5)
Endogenous Metabolite (5)
Serine/threonin kinase (5)
Calcium Channel (4)
VEGFR (4)
SGK (4)
Parasite (4)
Casein Kinase (4)
CaMK (4)
DNA/RNA Synthesis (4)
PDGFR (4)
Antifungal (3)
Influenza Virus (3)
p38 MAPK (3)
BCL (3)
NF-κB (3)
AMPK (3)
EGFR (3)
MAPK (2)
5-HT Receptor (2)
GRK (2)
HIV Protease (2)
FLT (2)
MEK (2)
Rho (2)
Phosphatase (2)
GSK-3 (2)
Sodium Channel (2)
Syk (2)
Wnt/beta-catenin (2)
COX (2)
MLK (2)
Myosin (2)
Antibiotic (2)
IGF-1R (2)
LDL (2)
FGFR (2)
Tyrosine Kinases (2)
PAI-1 (1)
Trk receptor (1)
STAT (1)
Ras (1)
TAM Receptor (1)
mTOR (1)
p53 (1)
Antiviral (1)
Reactive Oxygen Species (1)
CCR (1)
Topoisomerase (1)
c-Met/HGFR (1)
RAAS (1)
JNK (1)
ATPase (1)
Proton pump (1)
YAP (1)
PI3K (1)
Virus Protease (1)
Estrogen Receptor/ERR (1)
PARP (1)
Serine Protease (1)
Caspase (1)
RIP kinase (1)
JAK (1)
UGT (1)
Bcr-Abl (1)
AAK1 (AP2 associated kinase 1) (1)
Nucleoside Antimetabolite/Analog (1)
BTK (1)
Antifection (1)
Opioid Receptor (1)
NOS (1)
DNA Alkylation (1)
HSV (1)
Chk (1)
Aurora Kinase (1)
LRRK2 (1)
S1P Receptor (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE