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Tyrosine Kinase Inhibitor Library

カタログ番号 L2200
  ライブラリー構成化合物リスト   Excel SDF

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 1016 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • 1016種類のチロシンキナーゼ阻害剤を独自に収集したライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • ターゲットにはc-Kit、c-Met、EGFR、FGFR、SRC、JAK、SYK、Btk、Bcr-Ablなど
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L2200)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

EGFR (180)
VEGFR (157)
Apoptosis (144)
Autophagy (105)
FLT (99)
Src (97)
PDGFR (94)
FGFR (80)
c-Kit (73)
c-Met/HGFR (71)
Bcr-Abl (63)
JAK (61)
ALK (55)
BTK (50)
Tyrosine Kinases (48)
HER (46)
PKA (45)
IGF-1R (40)
c-RET (37)
TAM Receptor (36)
CDK (35)
Trk receptor (34)
Raf (32)
FAK (30)
c-Fms (28)
Aurora Kinase (28)
Syk (28)
TGF-beta/Smad (24)
DNA Alkylator/Crosslinker (23)
MEK (23)
PKC (22)
PI3K (19)
Akt (19)
ERK (19)
DYRK (17)
DNA Alkylation (16)
mTOR (15)
Ephrin Receptor (14)
CSF-1R (14)
ROS Kinase (13)
Endogenous Metabolite (13)
S6 Kinase (13)
DNA/RNA Synthesis (12)
p38 MAPK (11)
Discoidin Domain Receptor (DDR) (11)
Potassium Channel (11)
NF-κB (11)
Antibacterial (10)
GSK-3 (10)
5-HT Receptor (9)
ROS (8)
MAPK (8)
Chk (7)
Casein Kinase (7)
Tyrosinase (7)
Tie-2 (7)
Ferroptosis (6)
Microtubule Associated (6)
Drug Metabolite (6)
Mitophagy (6)
STAT (6)
MLK (6)
JNK (6)
DNA-PK (6)
Influenza Virus (6)
ROCK (6)
Serine/threonin kinase (6)
Calcium Channel (6)
ACK (5)
ATM/ATR (5)
Antibiotic (5)
TNF (5)
HDAC (5)
CaMK (5)
COX (5)
Reactive Oxygen Species (5)
PYK2 (5)
PPAR (4)
P450 (4)
Antifungal (4)
Hck (4)
Parasite (4)
SARS-CoV (4)
Pim (4)
PDE (4)
IκB/IKK (4)
Sodium Channel (4)
SGK (4)
p53 (3)
HIV Protease (3)
Dehydrogenase (3)
Ligands for Target Protein for PROTAC (3)
Adenosine Receptor (3)
PDK (3)
Adrenergic Receptor (3)
AChR (3)
IRAK (3)
Caspase (3)
RIP kinase (3)
IL Receptor (3)
PLK (3)
HSP (3)
Histamine Receptor (3)
Virus Protease (3)
MNK (2)
Beta Amyloid (2)
HCV Protease (2)
DHFR (2)
Phospholipase (2)
Interleukin (2)
MMP (2)
MAO (2)
Topoisomerase (2)
IRE1 (2)
LDL (2)
GRK (2)
Sigma receptor (2)
AMPK (2)
GluR (2)
Antioxidant (2)
Myosin (2)
AhR (1)
HIF (1)
p97 (1)
DNA Methyltransferase (1)
Reverse Transcriptase (1)
HIF/HIF Prolyl-Hydroxylase (1)
GPR (1)
Ligand for E3 Ligase (1)
CRISPR/Cas9 (1)
DAPK (1)
Hippo pathway (1)
Gap Junction Protein (1)
Melanin-concentrating Hormone Receptor (MCHR) (1)
RSV (1)
Estrogen Receptor/ERR (1)
Aryl Hydrocarbon Receptor (1)
Glucokinase (1)
NAMPT (1)
Nucleoside Antimetabolite/Analog (1)
cell cycle arrest (1)
Serotonin Transporter (1)
Antifolate (1)
Serine Protease (1)
Rho (1)
Wnt/beta-catenin (1)
Phosphatase (1)
Haspin Kinase (1)
CETP (1)
NADPH (1)
Na+/Ca2+ Exchanger (1)
IFNAR (1)
YAP (1)
Estrogen/progestogen Receptor (1)
Integrin (1)
Histone Methyltransferase (1)
ROR (1)
Carbonic Anhydrase (1)
PROTACs (1)
E1/E2/E3 Enzyme (1)
Mitochondrial Metabolism (1)
MELK (1)
DUB (1)
PAI-1 (1)
transporter (1)
Histone Acetyltransferase (1)
Sirtuin (1)
LRRK2 (1)
TLR (1)
Prostaglandin Receptor (1)
Antiviral (1)
P-gp (1)
BCRP (1)
Norepinephrine (1)
Monoamine Transporter (1)
Epigenetic Reader Domain (1)
Lipoxygenase (1)
PAD (1)
Mdm2 (1)
CXCR (1)
CCR (1)
HSV (1)
FAAH (1)
Hedgehog/Smoothened (1)
BCL (1)
PROTAC Linker (1)
PTEN (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE