ホーム 計算ツール
代理店ログイン

Anti-Hypertension Compound Library

カタログ番号 L7110
  ライブラリー構成化合物リスト   Excel SDF

Hypertension (hypertension) is a clinical syndrome characterized by increased arterial blood pressure (systolic and/or diastolic) in the body circulation (systolic blood pressure ≥ 140 mm Hg and diastolic blood pressure ≥ 90 mm Hg), often accompanied by clinical syndromes including metabolic disorders of fat and glucose, functional or organic changes in the heart, brain, kidney, and retina. Hypertension is the most common chronic disease and is the most important risk factor for cardiovascular and cerebrovascular diseases. The results of several studies suggest that intervention of blood pressure, early prevention and treatment of hypertension can help reduce the risk of cardiovascular disease.

Drugs for the treatment of hypertension are divided into five main categories.

1. Angiotensin-converting enzyme inhibitor (ACEI): Their mechanism of action is mainly based on the inhibition of the angiotensin-converting enzyme so that the secretion of angiotensin, aldosterone and vasopressin is reduced. The reduction of these substances can cause a series of effects such as vasodilation, reduction of vascular peripheral resistance, increase of water and sodium discharge, and reduction of blood volume, thus bringing down blood pressure. In addition, ACEI drugs have the effect of blocking the hydrolysis of bradykinin, which can increase the concentration of bradykinin as well as the secretion of prostaglandins that effectively dilate blood vessels and lower blood pressure. Examples include Captopril, Enalapril, Fosinopril, Lisinopril, etc.

2. Angiotensin receptor antagonist (ARB): Their mechanism of action is similar to that of ACEI, which inhibits the secretion of angiotensin and lowers blood pressure. ARB drugs are widely favored because unlike ACEI drugs, they do not lead to hacking cough. Examples of ARB drugs include Valsartan, Losartan, Telmisartan, Irbesartan, etc.

3. β-receptor antagonist: Their Anti-hypertension mechanism is mainly based on the reduction of cardiac blood output, where the body produces an adaptive response, causing a reduction in peripheral vascular resistance and blood pressure. At the same time, the β-receptors are blocked, sympathetic nerve fiber nerve conduction is reduced, and the release of norepinephrine is decreased, thus the blood pressure is further decreased. Examples of β-receptor antagonist drugs include Atenolol, Metoprolol, Bisoprolol, Carvedilol, etc.

4. Calcium Chanel Blocker (CCB): They mainly prevent the transfer of calcium ions from extracellular to intracellular, so that the intracellular calcium ion concentration is reduced, thus reducing the contractility of cardiomyocytes, and also reducing the excitability of the sinoatrial node and the conduction of the atrioventricular node, achieving a decrease in blood pressure. In addition, CCB drugs have a powerful effect of dilating small arterial vessels. Examples of CCB drugs include nifedipine, amlodipine, etc.

5.diuretics: these drugs affect the kidney mainly by diuretic sodium excretion that reduces the extracellular volume and decreases peripheral vascular resistance. Therefore, the Anti-hypertension effect of this class of drugs is smooth and slow, with a relatively long duration. According to drug classification, there are thiazide diuretics such as hydrochlorothiazide, tab diuretics such as furosemide, and potassium-protective diuretics such as spironolactone.

TargetMol Anti-hypertension Compound Library is a collection of 524 hypertension-related small molecules, including compounds with Anti-hypertension effects and compounds that act on hypertension-related targets, that support your research or related drug screening.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
Get quote

製品概要

  • ハイスループットスクリーニング(HTS)、ハイコンテンツスクリーニング(HCS)に最適な 678 種類の高血圧関連低分子化合物を収集
  • ターゲットはACE、Caチャネル、β-アドレナリン受容体、HMG-CoA還元酵素など
  • 化合物の概要、化学構造、標的、活性、IC50値など、詳細な情報を提供
  • NMR と HPLC/LCMS により高純度と高品質を担保
  • 本製品の化合物はいずれも別途納品可能

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L7110)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Adrenergic Receptor (155)
Calcium Channel (137)
Autophagy (77)
Dopamine Receptor (69)
RAAS (58)
PPAR (55)
5-HT Receptor (49)
Apoptosis (48)
AMPK (40)
Endogenous Metabolite (39)
Potassium Channel (30)
P450 (28)
AChR (28)
Histone Acetyltransferase (27)
HMG-CoA Reductase (21)
Antibacterial (17)
Histamine Receptor (17)
Epigenetic Reader Domain (16)
Prostaglandin Receptor (15)
BACE (13)
NF-κB (12)
Sodium Channel (12)
COX (11)
Ferroptosis (11)
Influenza Virus (11)
Endothelin Receptor (9)
Acetyl-CoA Carboxylase (9)
PDE (9)
Beta-Secretase (8)
Parasite (8)
Mitophagy (7)
Antibiotic (7)
Norepinephrine (7)
Reactive Oxygen Species (7)
Carbonic Anhydrase (7)
P-gp (7)
Antifungal (6)
CaMK (6)
Glucocorticoid Receptor (6)
ROCK (6)
MRP (5)
TRP/TRPV Channel (5)
ATPase (5)
GABA Receptor (5)
Adenosine Receptor (4)
STAT (4)
Nrf2 (4)
TGF-beta/Smad (4)
PKC (4)
Guanylate cyclase (4)
Opioid Receptor (4)
VEGFR (4)
iGluR (4)
Tyrosinase (3)
MAO (3)
Anti-infection (3)
Thrombin (3)
Drug Metabolite (3)
Hydroxylase (3)
Monoamine Transporter (3)
HIV Protease (3)
SIK (3)
Akt (3)
AChE (3)
RSV (3)
PI3K (3)
Monoamine Oxidase (3)
MMP (3)
Neprilysin (3)
PKA (3)
TNF (3)
Beta Amyloid (3)
Imidazoline Receptor (3)
Interleukin (2)
EGFR (2)
HDAC (2)
DNA/RNA Synthesis (2)
transporter (2)
Androgen Receptor (2)
Aminopeptidase (2)
NO Synthase (2)
Lipoxygenase (2)
Chloride channel (2)
LDL (2)
GluR (2)
Phosphatase (2)
PARP (2)
NMDAR (2)
ABC (2)
Na-K-Cl cotransporter (2)
ERK (2)
Serotonin Transporter (2)
Fatty Acid Synthase (2)
Arrestin (2)
Virus Protease (2)
Wnt/beta-catenin (2)
IL Receptor (2)
Src (2)
Bradykinin Receptor (2)
Histone Methyltransferase (2)
Reverse Transcriptase (1)
Retinoid Receptor (1)
Integrin (1)
cAMP (1)
Dehydrogenase (1)
ASK (1)
YAP (1)
Antioxidant (1)
AhR (1)
LTR (1)
Na+/Ca2+ Exchanger (1)
Proteasome (1)
GSK-3 (1)
CRISPR/Cas9 (1)
DNA Methyltransferase (1)
p53 (1)
HIF/HIF Prolyl-Hydroxylase (1)
Reductase (1)
Sigma receptor (1)
Ras (1)
NADPH-oxidase (1)
RAR/RXR  (1)
GPR (1)
NADPH (1)
Neurokinin receptor (1)
Gap Junction Protein (1)
JNK (1)
Glutathione Peroxidase (1)
c-RET (1)
Phospholipase (1)
MEK (1)
Adiponectin receptor (1)
Serine Protease (1)
SARS-CoV (1)
FAAH (1)
Hedgehog/Smoothened (1)
PAK (1)
PDGFR (1)
P2X Receptor (1)
Sirtuin (1)
ROS (1)
Epoxide Hydrolase (1)
BCL (1)
HCN Channel (1)
BCRP (1)
ATP Citrate Lyase (1)
HSV (1)
Vasopressin Receptor (1)
Aurora Kinase (1)
CDK (1)
IGF-1R (1)
Serine/threonin kinase (1)
Antiviral (1)
Caspase (1)
Annexin A (1)
GST (1)
IκB/IKK (1)
Anion Exchanger (1)
N-Acetylglucosaminyltransferase (1)
Rho (1)
OAT (1)
PAFR (1)
MAPK (1)
Lipid (1)
SGLT (1)
Cysteine Protease (1)
mTOR (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
E1/E2/E3 Enzyme (1)
HER (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE