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Approved Drug Library

カタログ番号 L1000
  ライブラリー構成化合物リスト   Excel SDF

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

Approved drugs all have known and well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization. Hits from this set will provide a significant head start in any drug optimization program.

In addition, a growing number of compounds have been identified from this library that can functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a combination of several molecules.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 承認薬2808種類からなる当社独自の化合物コレクション
  • ドラッグリポジショニングや細胞分化誘導において強力なツール
  • がん、心血管疾患、神経科学、免疫/炎症など、さまざまな研究分野をカバー
  • 化合物の概要、化学構造、標的、活性、IC50値など、詳細な情報を提供
  • NMR と HPLC/LCMS により高純度と高品質を担保し、偽陽性率を低減

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1000)

Publications Cited TargetMol Libraries

1. Nature. 2020, 582: 289-293. 2. Nucleic Acids Research. 2021. 3. Nature Communications. 2023, 14(1): 7574. 4. Protein & Cell. 2021, 12(11): 877-888. 5. Nature Communications. 2021, 12(1): 1-12. 6. Cell Reports. 2022: 111117. 7. Cancer Letters. 2022: 216011. 8. Cell Death & Disease. 2023, 14(1): 11. 9. Cell & Bioscience. 2022, 12(1): 1-17.
10. Cell Reports. 2022, 39(1): 110643. 11. Pharmacological Research. 2021: 105860. 12. Acta Pharmacologica Sinica. 2023: 1-14. 13. Elife. 2021, 10: e63810. 14. Mbio. 2021, 12(1): e02754-20. 15. European Journal of Medicinal Chemistry. 2023: 115893. 16. Elife. 2021, 10: e67381. 17. Communications Biology. 2022, 5(1): 1-13. 18. Molecular Cancer Therapeutics. 2018 Feb;17(2):419-431. 19. Computational and Structural Biotechnology Journal. 2022. 20. iScience. 2023. 21. Frontiers in chemistry. 2022, 10. 22. Bioorganic Chemistry. 2022: 106191. 23. Frontiers in Cellular and Infection Microbiology. 2021: 1280. 24. Bioorganic Chemistry. 2020. 25. Scientific Reports. 2022, 12(1): 1-16. 26. Methods. 2022, 205: 247-262. 27. Cancer Science. 2021, 112(11): 4722. 28. Cognitive computation. 2021 Feb 2;1-13. 29. Antiviral Research. 2020, 174: 104701. 30. Toxicology and Applied Pharmacology. 2023: 116792. 31. Virology. 2022. 32. Investigational New Drugs. 2019 May 14: 1-10. 33. Acta Biochimica et Biophysica Sinica. 2021. 34. Structural Chemistry. 2022: 1-13. 35. Chinese Medical Journal. 2020, 133(9): 1051-1056. 36. Interdisciplinary Sciences, Computational Life Sciences. 2020, 12: 368-376. 37. Researchsquare. 2023. 38. BVS. 2020. 39. Journal of Southern Medical University. 2022, 42(4): 554-560. 40. Journal of Southern Medical University. 2021, 41(12): 1835-1842. 41. Strategies to Overcome Superbug Invasions. 2021: 269-287. 42. bioRxiv. 2020. 43. Research square. 2020. 44. Researchsquare. 2020. 45. Cell Stem Cell. 2022 Apr 29(4) 545–558. 46. Science Bulletin. 2022. 47. Science Translational Medicine. 2022, 14(656): eabn3231. 48. Science Advances. 2023, 9(9): eade3760. 49. Nature Biotechnology. 2021, 39(11): 1444-1452. 50. Nature Communications. 2022, 13(1): 1-15.. 51. Nature Communications. 2023, 14(1): 1020.. 52. Nature Communications. 2023, 14(1): 2756.. 53. Blood. 2021, 137(11): 1478-1490. 54. Advanced Science. 2020, 7(16): 2000925. 55. Angewandte Chemie. 2021. 56. Acta Pharmaceutica Sinica B. 2022. 57. Bone Research. 2023, 11(1): 54. 58. Pharmacology & Therapeutics. (2021): 107930. 59. Journal of Cell Biology. 2022, 221(5): e202112024. 60. Tan Q, Wu D, Lin Y, et al.Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs.Bioorganic Chemistry.2024: 107261. 61. Duo L, Chen Y, Liu Q, et al.Discovery of Novel SOS1 Inhibitors Using Machine Learning.RSC Medicinal Chemistry.2024 62. Zou X, Yin J, Lei Q, et al.Bosutinib Laden Three-Dimensional Printed Zein Scaffolds Promote Osteogenesis.ACS Applied Polymer Materials.2024 63. Wang C, Ji Y, Huo X, et al.Discovery of Salifungin as a Repurposed Antibiotic against Methicillin-Resistant Staphylococcus aureus with Limited Resistance Development.ACS Infectious Diseases.2024 64. Ma Y, Song Y, Wang J, et al.Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening.Future Medicinal Chemistry.2024 (0). 65. Wang D, He J, Liu S, et al.Anlotinib synergizes with venetoclax to induce mitotic catastrophe in acute myeloid leukemia.Cancer Letters.2024: 216970.
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化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE