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Chromatin Modification Compound Library

カタログ番号 L8300
  ライブラリー構成化合物リスト   Excel SDF

Chromatin modification, also called Chromatin remodeling, is the rearrangement of chromatin from a condensed state to a transcriptionally accessible state, allowing transcription factors or other DNA binding proteins to access DNA and control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. Chromatin remodeling is highly implicated in epigenetics. Epigenetic modifications to histone proteins such as methylation/demethylation and acetylation/deacetylation can alter the structure of chromatin resulting in transcriptional activation or repression. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.

Chromatin Modification Compound Library from TargetMol is a unique collection of 250 compounds targeting chromatin remodeling pathways that can be used for high throughput and high content screening.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • クロマチンリモデリング経路に関連する250化合物からなるHTSおよびHCSに最適な当社独自のコレクション
  • 化合物の概要,化学構造,標的,活性,IC50値など詳細な情報を提供
  • NMRとHPLC/LCMSにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L8300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

HDAC (107)
Histone Methyltransferase (62)
Apoptosis (54)
Epigenetic Reader Domain (44)
Autophagy (29)
Histone Demethylase (24)
Sirtuin (18)
DNA Methyltransferase (11)
Histone Acetyltransferase (8)
HIV Protease (6)
Mitophagy (5)
COX (4)
Monoamine Oxidase (3)
Influenza Virus (3)
PI3K (3)
Antibacterial (3)
PDE (3)
Nrf2 (2)
HSV (2)
JAK (2)
Endogenous Metabolite (2)
Dehydrogenase (2)
NF-κB (2)
Adenosine Receptor (2)
MAO (2)
Nucleoside Antimetabolite/Analog (2)
Antibiotic (2)
TNF (2)
AChR (2)
DNA/RNA Synthesis (2)
Virus Protease (2)
Histamine Receptor (2)
Sodium Channel (2)
Dopamine Receptor (2)
transporter (1)
AMPK (1)
p53 (1)
IκB/IKK (1)
Carboxypeptidase (1)
Phospholipase (1)
GABA Receptor (1)
FLT (1)
NOD (1)
Tyrosinase (1)
5-HT Receptor (1)
PAD (1)
Akt (1)
PPAR (1)
DNA-PK (1)
Ligands for Target Protein for PROTAC (1)
Ferroptosis (1)
Antifungal (1)
NADPH (1)
RAAS (1)
PKA (1)
HBV (1)
Tyrosine Kinases (1)
Parasite (1)
EGFR (1)
Adrenergic Receptor (1)
Bcr-Abl (1)
Gamma-secretase (1)
CDK (1)
Mitochondrial Metabolism (1)
BCL (1)
Reactive Oxygen Species (1)
CCR (1)
Lipoxygenase (1)
mTOR (1)
HER (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE