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Cytokine Inhibitor Library

カタログ番号 L3600
  ライブラリー構成化合物リスト   Excel SDF

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling, modulate the balance between humoral and cell-based immune responses, and are heavily involved in autoimmune and inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases.

Cytokines act through receptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from TargetMol, containing 604 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • サイトカインのシグナル伝達をターゲットとする604化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、ほとんどの化合物は承認薬として上市済み
  • ターゲットはIL、CSF、IFN、TNF、TGF-βファミリー、成長因子、ケモカインファミリーなどの各種サイトカイン
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L3600)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

EGFR (130)
VEGFR (129)
TNF (79)
Apoptosis (77)
PDGFR (76)
FGFR (72)
Autophagy (61)
IL Receptor (60)
c-Kit (54)
TGF-beta/Smad (48)
c-Met/HGFR (47)
FLT (43)
Src (32)
CXCR (31)
NF-κB (30)
CCR (29)
Interleukin (28)
IGF-1R (27)
ALK (26)
HER (25)
Bcr-Abl (21)
c-RET (19)
JAK (18)
COX (16)
c-Fms (16)
Endogenous Metabolite (15)
Antibacterial (14)
Raf (14)
HIV Protease (14)
TAM Receptor (13)
RIP kinase (12)
CDK (11)
CSF-1R (11)
Potassium Channel (11)
Aurora Kinase (9)
p38 MAPK (9)
Tyrosine Kinases (8)
ERK (8)
STAT (8)
IFNAR (8)
Drug Metabolite (7)
Trk receptor (7)
Parasite (7)
FAK (7)
BTK (6)
NO Synthase (6)
DNA/RNA Synthesis (6)
5-HT Receptor (6)
Tyrosinase (6)
JNK (5)
MEK (5)
PDE (5)
Akt (5)
PKC (5)
IκB/IKK (5)
Reactive Oxygen Species (5)
Caspase (5)
Ferroptosis (5)
Sodium Channel (4)
Influenza Virus (4)
Ephrin Receptor (4)
PKA (4)
MLK (4)
MMP (4)
Chk (4)
TLR (4)
S6 Kinase (4)
P450 (4)
NOD (4)
ROS (4)
STING (3)
PI3K (3)
Ligand for E3 Ligase (3)
HDAC (3)
HCV Protease (3)
AMPK (3)
GSK-3 (3)
PPAR (3)
Discoidin Domain Receptor (DDR) (3)
Calcium Channel (3)
Virus Protease (3)
ROS Kinase (3)
Tie-2 (3)
NOD-like Receptor (NLR) (3)
Molecular Glues (3)
Mitophagy (3)
NOS (3)
Anti-infection (3)
GABA Receptor (2)
MAPK (2)
Hck (2)
Adrenergic Receptor (2)
mTOR (2)
Casein Kinase (2)
IRE1 (2)
P-gp (2)
Syk (2)
Chloride channel (2)
Mitochondrial Metabolism (2)
transporter (2)
Histamine Receptor (2)
Antifungal (2)
PYK2 (2)
Beta Amyloid (1)
Reverse Transcriptase (1)
CFTR (1)
ATPase (1)
HIF/HIF Prolyl-Hydroxylase (1)
AChR (1)
Antibiotic (1)
Dehydrogenase (1)
Microtubule Associated (1)
Estrogen/progestogen Receptor (1)
PDK (1)
Phospholipase (1)
Proton pump (1)
PLK (1)
Integrin (1)
Gap Junction Protein (1)
ROR (1)
SGK (1)
NADPH-oxidase (1)
LTR (1)
Nrf2 (1)
VDA (1)
LDL (1)
E1/E2/E3 Enzyme (1)
Annexin A (1)
Topoisomerase (1)
Glucocorticoid Receptor (1)
iGluR (1)
Amylase (1)
ROCK (1)
TRP/TRPV Channel (1)
Glucokinase (1)
BCL (1)
NAMPT (1)
Leukotriene Receptor (1)
cell cycle arrest (1)
Serine Protease (1)
PARP (1)
Wnt/beta-catenin (1)
Estrogen Receptor/ERR (1)
HBV (1)
MRP (1)
c-Myc (1)
Antifection (1)
DNA Alkylation (1)
Histone Acetyltransferase (1)
Progesterone Receptor (1)
Sirtuin (1)
LRRK2 (1)
SARS-CoV (1)
Prostaglandin Receptor (1)
Antiviral (1)
MNK (1)
AChE (1)
PGE Synthase (1)
Antioxidant (1)
Adenosine Receptor (1)
FAAH (1)
Na+/Ca2+ Exchanger (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
CaMK (1)
Arrestin (1)
Epigenetic Reader Domain (1)
Lipoxygenase (1)
ACK (1)
PAD (1)
NADPH (1)
Lipase (1)
PKM (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE