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Cytoskeletal Signaling Pathway Compound Library

カタログ番号 L1310
  ライブラリー構成化合物リスト   Excel SDF

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including bacteria and archaea. It extends from the cell nucleus to the cell membrane and is composed of similar proteins in the various organisms. In eukaryotes, it is composed of three main components, microfilaments, intermediate filaments and microtubules, and these are all capable of rapid growth or disassembly dependent on the cell's requirements. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microtubules provide structure and shape to eukaryotic cells and help localize membrane-enclosed organelles. Intermediate filaments have great tensile strength, and their main function is to enable cells to withstand the mechanical stress that occurs when cells are stretched.

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, establishment of the intracellular organization of the cytoplasm, establishment of cell polarity, and many other functions that are essential for cellular homeostasis and survival. Many diseases have now been associated with abnormalities in cytoskeletal and nucleoskeletal proteins, including neurodegeneration such as Alzheimer's Disease (AD) with the accumulation of amyloid beta peptide, and the intracellular neurofibrillary tangles that composed of paired helical filaments of the microtubule-associated protein, tau; cancer (invasion) with cytoskeleton aberration like reduced microtubule polymerization, etc.

TargetMol’s Cytoskeletal Signaling Pathway Compound Library collects 759 compounds related to cytoskeletal regulation with targets on Microtubule/Tubulin, Kinesin, PKC, MAPK, etc. It can be used for research in cytoskeletal signaling pathway, cytoskeleton associated disease, and drug discovery.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 細胞骨格に関連する759種類の生物活性化合物を独自に収集したライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • ターゲットには微小管/チューブリン、キネシン、PKC、MAPKなど
  • 一部に承認薬有効成分を含む
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • 化合物の概要、化学構造、標的、生物活性など詳細な情報を提供
  • NMRとHPLC/LCMSなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1310)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Apoptosis (142)
Microtubule Associated (108)
Autophagy (102)
p38 MAPK (96)
Akt (92)
Wnt/beta-catenin (90)
PKC (77)
Bcr-Abl (62)
HSP (56)
MAPK (49)
ROCK (40)
Integrin (35)
Src (35)
NF-κB (30)
FAK (29)
ERK (27)
PKA (22)
PI3K (22)
Parasite (21)
Antibacterial (20)
VEGFR (19)
Endogenous Metabolite (19)
Kinesin (19)
c-Kit (18)
PAK (18)
CDK (17)
mTOR (16)
PDGFR (15)
JNK (15)
Myosin (14)
Antibiotic (13)
PARP (13)
Caspase (12)
Reactive Oxygen Species (12)
Rho (12)
TNF (11)
COX (11)
S6 Kinase (11)
BCL (10)
IGF-1R (10)
FGFR (9)
STAT (9)
Aurora Kinase (9)
Casein Kinase (8)
Antifungal (8)
FLT (8)
GSK-3 (8)
Dynamin (7)
EGFR (7)
AMPK (7)
Raf (7)
MEK (6)
Influenza Virus (6)
HIV Protease (6)
ALK (6)
Ras (6)
JAK (6)
Gap Junction Protein (6)
ASK (5)
Topoisomerase (5)
CaMK (5)
MMP (5)
IL Receptor (5)
c-Met/HGFR (5)
ATPase (5)
PYK2 (5)
Tyrosine Kinases (5)
Serine/threonin kinase (5)
NO Synthase (5)
PPAR (5)
Calcium Channel (4)
TLR (4)
SGK (4)
Lipoxygenase (4)
Syk (4)
p53 (4)
Ferroptosis (4)
PDK (4)
GPR (4)
DNA/RNA Synthesis (4)
SARS-CoV (3)
S1P Receptor (3)
Porcupine (3)
ACK (3)
HER (3)
c-Fms (3)
HSV (3)
Trk receptor (3)
HIF (3)
P-gp (3)
LDL (3)
Gamma-secretase (3)
Serine Protease (3)
Antifection (3)
Mitochondrial Metabolism (3)
c-RET (3)
Virus Protease (3)
Mitophagy (3)
transporter (2)
Prostaglandin Receptor (2)
Ephrin Receptor (2)
MLK (2)
Nrf2 (2)
Antiviral (2)
AChR (2)
MNK (2)
Beta Amyloid (2)
HDAC (2)
Monoamine Oxidase (2)
TGF-beta/Smad (2)
Guanylate cyclase (2)
Carbonic Anhydrase (2)
HCV Protease (2)
MyD88 (2)
Antioxidant (2)
LPL Receptor (2)
RAAS (2)
Adrenergic Receptor (2)
GRK (2)
Drug Metabolite (2)
BTK (2)
Hck (2)
DNA Alkylation (2)
KSP (2)
PTEN (2)
Epigenetic Reader Domain (2)
Chk (2)
Cannabinoid Receptor (1)
Complement System (1)
Potassium Channel (1)
PERK (1)
NADPH (1)
DYRK (1)
Adenosine Receptor (1)
IRAK (1)
Arginase (1)
Tie-2 (1)
YAP (1)
HIF/HIF Prolyl-Hydroxylase (1)
Estrogen/progestogen Receptor (1)
AhR (1)
Ligands for Target Protein for PROTAC (1)
DNA (1)
DHFR (1)
DUB (1)
PROTACs (1)
Histamine Receptor (1)
Glutathione Peroxidase (1)
Glucosidase (1)
TRP/TRPV Channel (1)
Hedgehog/Smoothened (1)
MELK (1)
Aminopeptidase (1)
Methionine Adenosyltransferase (MAT) (1)
Mdm2 (1)
IκB/IKK (1)
GST (1)
PDE (1)
Aryl Hydrocarbon Receptor (1)
LRRK2 (1)
NAMPT (1)
Phosphatase (1)
Aromatase (1)
Glucokinase (1)
CRISPR/Cas9 (1)
FXR (1)
Nucleoside Antimetabolite/Analog (1)
Androgen Receptor (1)
5-HT Receptor (1)
PLK (1)
Estrogen Receptor/ERR (1)
HBV (1)
MRP (1)
Apelin receptor (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE