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Glutamine Metabolism Compound Library

カタログ番号 L2550
  ライブラリー構成化合物リスト   Excel SDF

L-glutamine is a non-essential amino acid that is often simply called glutamine. It is produced by the body. Glutamine is synthesized from NH4+ and glutamate. The conversion of glutamate to glutamine is regulated by glutamine synthetase (GS) and is a key step in nitrogen metabolism. Although normally synthesized in adequate amounts, endogenous glutamine production may be inadequate during periods of metabolic stress or under the condition of disease.

Glutamine is crucial for many metabolic functions, including protein and glutathione synthesis, energy production, maintenance of optimal antioxidant status, and immune function. Glutamine is the main metabolic substrate of macrophages and important for the function of macrophages; Glutamine is an important biosynthetic precursor for amino acid, protein and nucleic acid synthesis; Glutamine serves as a source of fuel for the cells lining the intestines, and without it, these cells may waste away; Glutamine is significantly involved in the synthesis of glutathione, a very important intracellular antioxidant and detoxication factor.

Cancer cells undergo a reprogramming of metabolism in order to maintain bioenergetics, redox status, cell signaling and biosynthesis, in what is often a poorly vascularized, nutrient-deprived microenvironment. A metabolic characteristic of many cancer cells is a dependence on an exogenous supply of glutamine, exhibiting “glutamine addiction”. Glutamine enters the cell through the amino acid transporter, ASCT2/SLC1A5, and is converted to glutamate in the mitochondria through a deamination reaction catalyzed by glutaminase (GLS). Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), which produce their corresponding amino acid in addition to α-KG, a process termed glutaminolysis. Humans express 4 isoforms of glutaminase which is the restriction and initiation enzyme in the glutaminolytic pathway. GLS encodes 2 types of kidney-type glutaminase with a high activity and low Km. GLS2 encodes 2 forms of liver-type glutaminase with a low activity and allosteric regulation.

Glutamine coordinates intracellular signaling to promote cancer growth in addition to acting as an important substrate for carbon and nitrogen production. For example, MYC transcriptionally represses miR-23a/b, leading to higher expression of mitochondrial glutaminase. Glutamine stimulates mTORC1 activity and in turn, impairs autophagy initiation through the negative regulation of ULK1 by several mechanisms. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

TargetMol owns a unique collection of 565 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for research in glutamine metabolic processes and drug discovery.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • グルタミン代謝に関連する565化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)、ハイコンテンツスクリーニング(HCS)、グルタミン代謝および関連するがん研究に最適
  • ターゲットにはグルタミナーゼ(GLS)、ASCT2、グルタミン酸デヒドロゲナーゼ、c-Mycなど
  • 一部にFDAによって承認を受けた化合物を含む
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLC/LCMSにより高純度と高品質を担保

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L2550)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Autophagy (123)
Apoptosis (105)
Akt (80)
mTOR (76)
PI3K (55)
Endogenous Metabolite (44)
HIF/HIF Prolyl-Hydroxylase (39)
ERK (35)
Raf (33)
Dehydrogenase (29)
AMPK (29)
Glucocorticoid Receptor (28)
GluR (28)
Ferroptosis (25)
HIF (25)
NF-κB (24)
Ras (24)
p53 (22)
Reactive Oxygen Species (21)
Antibacterial (20)
DNA-PK (19)
Sirtuin (18)
S6 Kinase (17)
SGLT (15)
c-Myc (15)
MEK (14)
Glutathione Peroxidase (12)
iGluR (11)
Mitophagy (11)
Isocitrate Dehydrogenase (IDH) (10)
HMG-CoA Reductase (10)
NADPH (9)
VEGFR (9)
Antibiotic (9)
transporter (9)
COX (9)
p38 MAPK (9)
PDGFR (8)
HIV Protease (8)
Rho (8)
PKM (8)
CDK (8)
PKC (8)
Src (8)
E1/E2/E3 Enzyme (7)
TNF (7)
PKA (7)
JNK (7)
P450 (6)
GABA Receptor (6)
Epigenetic Reader Domain (6)
DNA/RNA Synthesis (6)
Influenza Virus (6)
ATM/ATR (6)
Caspase (6)
Mdm2 (6)
Sodium Channel (6)
PPAR (6)
Parasite (6)
Amino Acids and Derivatives (6)
FLT (5)
Glutaminase (5)
ROS (5)
c-RET (5)
Potassium Channel (5)
STAT (5)
AChR (5)
c-Kit (5)
ROCK (5)
LRRK2 (4)
Nrf2 (4)
GST (4)
Mitochondrial Metabolism (4)
NMDAR (4)
Virus Protease (4)
PDK (4)
Antifungal (4)
Estrogen/progestogen Receptor (4)
NADPH-oxidase (4)
MMP (4)
HDAC (3)
MAPK (3)
Lipoxygenase (3)
Aurora Kinase (3)
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HSV (3)
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GPX (3)
Calcium Channel (3)
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GlyT (3)
Aryl Hydrocarbon Receptor (3)
Glutathione reductase (2)
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Antiviral (2)
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GTPase (2)
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Transferase (2)
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NOS (2)
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DNA Alkylator/Crosslinker (2)
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EGFR (2)
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Interleukin (2)
5-HT Receptor (2)
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Retinoid Receptor (1)
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CRISPR/Cas9 (1)
FAK (1)
SGK (1)
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ROS Kinase (1)
PI4K (1)
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OXPHOS (1)
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Glucagon Receptor (1)
Drug Metabolite (1)
Gamma-secretase (1)
Annexin A (1)
NO Synthase (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE