ホーム 計算ツール
代理店ログイン

GPCR Compound Library

カタログ番号 L1500
  ライブラリー構成化合物リスト   Excel SDF

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. GPCRs are involved in nearly every aspect of animal life, from early development and heart function to neuronal activity. Mutations in GPCRs are linked to a number of human diseases. GPCRs are an important drug target and approximately 34% of the marketed drugs target 108 members of this family, with an additional 66 receptors targeted by agents that are/were in clinical trials. GPCR-based drug discovery remains active campaigns in major pharmaceutical companies. To date more than 140 orphan GPCRs, whose endogenous ligands are unknown, are the focus of an intense drug discovery effort in many programs.

Specifically, the optimal ligands to GPCRs need to possess high affinity and specificity for the target protein, and reasonable membrane permeability for biological activity in whole cell assays and in vivo models. GPCR Compound Library from TargetMol, a focused small molecule libraries developed against particular GPCRs containing 1940 GPCR-active agents for GPCR drug discovery.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
Get quote

製品概要

  • GPCRに対して活性を持つ1940化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • オーファンGPCRをターゲットとすることで新薬候補発見に高い期待
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、一部に承認薬を含む
  • ターゲットには5-HT受容体、ドーパミン受容体、オピオイド受容体、アドレナリン受容体、mGluR、カナビノイド受容体、ETA受容体など
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1500)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

5-HT Receptor (368)
Adrenergic Receptor (259)
Dopamine Receptor (230)
Histamine Receptor (175)
GPR (104)
Prostaglandin Receptor (98)
Adenosine Receptor (95)
Opioid Receptor (88)
Ras (72)
Cannabinoid Receptor (68)
Apoptosis (67)
Autophagy (65)
Endogenous Metabolite (62)
AChR (50)
CXCR (39)
S1P Receptor (37)
Hedgehog/Smoothened (34)
LPL Receptor (33)
Neurokinin receptor (32)
Sigma receptor (29)
Protease-activated Receptor (26)
Norepinephrine (26)
Serotonin Transporter (26)
Endothelin Receptor (24)
Antibacterial (24)
Glucagon Receptor (23)
SGLT (22)
Neuropeptide Y Receptor (21)
P2Y Receptor (21)
Calcium Channel (21)
cAMP (21)
Potassium Channel (20)
PDE (20)
Guanylate cyclase (19)
LPA Receptor (18)
OX Receptor (17)
GTPase (16)
Leukotriene Receptor (16)
Vasopressin Receptor (16)
P450 (15)
Bradykinin Receptor (14)
Rho (13)
GPCR19 (12)
Neurotensin Receptor (12)
Melanocortin Receptor (12)
NO Synthase (12)
Smo (12)
cholecystokinin (12)
Parasite (11)
GHSR (11)
Influenza Virus (11)
CaSR (10)
GRK (10)
COX (10)
Melatonin Receptor (10)
NF-κB (9)
Raf (9)
Sodium Channel (9)
Antibiotic (9)
Somatostatin (9)
Antifungal (8)
TRP/TRPV Channel (8)
PPAR (8)
PAFR (8)
CaMK (7)
HIV Protease (7)
Oxytocin Receptor (7)
Reactive Oxygen Species (7)
Annexin A (7)
Bombesin Receptor (7)
Arrestin (7)
Glucocorticoid Receptor (6)
Monoamine Oxidase (6)
IL Receptor (6)
MT Receptor (6)
CDK (6)
P-gp (6)
Lipoxygenase (6)
PKA (6)
PI3K (6)
LTR (6)
GNRH Receptor (6)
TSH Receptor (6)
AChE (6)
NOS (5)
CRFR (5)
Mitophagy (5)
Drug Metabolite (5)
GABA Receptor (5)
CGRP Receptor (5)
TNF (5)
HCV Protease (5)
Transferase (5)
HSP (4)
MAPK (4)
EGFR (4)
Phospholipase (4)
DNA/RNA Synthesis (4)
Akt (4)
Melanin-concentrating Hormone Receptor (MCHR) (4)
ROS (4)
P2X Receptor (4)
Histone Methyltransferase (4)
Virus Protease (4)
PKC (4)
ERK (4)
MAO (4)
HER (4)
NMDAR (4)
GluR (3)
FXR (3)
RAAS (3)
HDAC (3)
STAT (3)
Monoamine Transporter (3)
Caspase (3)
ABC (3)
Immunology/Inflammation related (3)
Ferroptosis (3)
VEGFR (3)
iGluR (3)
Anti-infection (3)
ROCK (3)
p38 MAPK (3)
Thrombin (3)
Adiponectin receptor (3)
Imidazoline Receptor (3)
CCR (3)
ATPase (3)
FAAH (3)
Glutathione Peroxidase (3)
MRP (2)
transporter (2)
HBV (2)
PAK (2)
Phosphatase (2)
DYRK (2)
Hydroxylase (2)
HIF (2)
Reductase (2)
PARP (2)
Estrogen/progestogen Receptor (2)
Syk (2)
EBI2/GPR183 (2)
Microtubule Associated (2)
Apelin receptor (2)
SARS-CoV (2)
Beta Amyloid (2)
MMP (2)
HSV (2)
LDL (2)
DNA (2)
Topoisomerase (2)
Dehydrogenase (1)
FLT (1)
Platelet aggregation (1)
PAD (1)
Gap Junction Protein (1)
Acyltransferase (1)
YAP (1)
Aurora Kinase (1)
Na+/Ca2+ Exchanger (1)
FGFR (1)
MEK (1)
Neuropeptide W (1)
IAP (1)
PTEN (1)
NADPH-oxidase (1)
Carbonic Anhydrase (1)
Stearoyl-CoA Desaturase (SCD) (1)
Adenylyl cyclase (1)
AhR (1)
FAK (1)
HIF/HIF Prolyl-Hydroxylase (1)
lysosomal autophagy (1)
ROR (1)
RXFP receptor (1)
Motilin Receptor (1)
FLAP (1)
Tyrosinase (1)
Mitochondrial Metabolism (1)
Angiotensin-converting Enzyme (ACE) (1)
Integrin (1)
Adenosine deaminase (1)
Epigenetic Reader Domain (1)
Wnt/beta-catenin (1)
PGE Synthase (1)
GST (1)
IκB/IKK (1)
c-Myc (1)
BCL (1)
Casein Kinase (1)
ATP Citrate Lyase (1)
Cysteine Protease (1)
GPX (1)
Free radical scavengers (1)
Antifolate (1)
Trk receptor (1)
LRRK2 (1)
Serine Protease (1)
Estrogen Receptor/ERR (1)
Proteasome (1)
Reverse Transcriptase (1)
GlyT (1)
Androgen Receptor (1)
Amylase (1)
RAR/RXR  (1)
NADPH (1)
PERK (1)
Glucosidase (1)
AMPK (1)
CRISPR/Cas9 (1)
Retinoid Receptor (1)
Progesterone Receptor (1)
GSK-3 (1)
PROTAC Linker (1)
Interleukin (1)
OCT (1)
TGF-beta/Smad (1)
RSV (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE