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HIF-1 Signaling Pathway Compound Library

カタログ番号 L8500
  ライブラリー構成化合物リスト   Excel SDF

Cell signaling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively.

As a key regulator of the hypoxia response, hypoxia inducible factor-1 (HIF-1) has been attracting more attention from scientists. HIF-1 is an evolutionarily conserved transcription factor that functions as a main regulator of gene expression in response to hypoxia. HIF-1 is functionally heterodimeric, composed of HIF-1β and one of three α subunits (HIF-1α, HIF-2α, or HIF-3α). All subunits are part of the basic helix-loop-helix superfamily of transcription factors, but its activity is primarily controlled by cellular levels of the HIF-1α subunit. As a transcriptional factor, the heterodimer HIF-1 recognizes and binds to the consensus sequence 5’-(A/G) CGTG-3’ named hypoxia-responsive elements (HREs) to activate the transcriptional activity of target genes. To date, more than 100 direct target genes of HIF-1 have been uncovered, which have been shown to be functionally involved in tumor metastasis, angiogenesis, energy metabolism, cell differentiation and apoptosis.

Intensive studies have clearly established the hypoxia/HIF signaling pathway as a master regulator of the vascular system. Accordingly, it represents an important therapeutic target for vascular diseases and cancer. Pharmacologically increased HIF function may aid in the treatment of a wide range of diseases, as HIF has been shown to be essential for phenomena as diverse as immune function, cartilage formation, and wound healing. Conversely, inhibition of HIF function could also have many applications: increased levels of HIF are seen in many cancers as well as in some cardiovascular diseases, including stroke, heart attack, and pulmonary hypertension.

To meet the need of research in oxygen-sensing pathways, TargetMol collects 1336 HIF-1 related small chemicals,involving PI3K-AKT, MAPK, Ubiquitination signaling pathways and targets such as HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome, etc.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • HIF-1に関連する1336種類の化合物を独自に収集したライブラリーで、虚血を伴う疾患やがんの治療および機序の研究に最適
  • ターゲットにはPI3K-AKT、MAPK、ユビキチン化シグナルなどの伝達経路およびHIF、HIFプロリルヒドロキシラーゼ、E1/E2/E3酵素、PI3K、MAPK、プロテアソームなどの因子
  • 一部に被験薬および承認薬を含む
  • 化合物の概要、化学構造、標的、生物活性など詳細な情報を提供
  • NMRとHPLCにより高純度と高品質を担保

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L8500)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Apoptosis (300)
Autophagy (235)
PI3K (151)
NF-κB (126)
COX (82)
Akt (81)
ERK (78)
p38 MAPK (74)
mTOR (72)
HDAC (60)
Raf (59)
Endogenous Metabolite (56)
Proteasome (55)
Ras (53)
TNF (50)
Antibacterial (46)
Src (46)
AMPK (44)
JNK (41)
MEK (40)
GSK-3 (39)
E1/E2/E3 Enzyme (39)
HIF/HIF Prolyl-Hydroxylase (38)
CDK (34)
MAPK (34)
Reactive Oxygen Species (32)
DUB (30)
HIF (30)
IL Receptor (29)
VEGFR (28)
DNA-PK (28)
S6 Kinase (27)
Ferroptosis (27)
Caspase (23)
IκB/IKK (23)
TGF-beta/Smad (23)
Sirtuin (22)
ROS (21)
Influenza Virus (20)
TLR (19)
ATM/ATR (19)
HIV Protease (19)
p53 (19)
Bcr-Abl (18)
HSP (18)
DPP-4 (18)
Mitophagy (17)
EGFR (17)
STAT (16)
c-Kit (15)
Antibiotic (15)
PKC (15)
PDGFR (14)
Virus Protease (14)
Parasite (14)
JAK (13)
FLT (13)
PPAR (13)
Antioxidant (13)
Mdm2 (13)
MMP (12)
Aurora Kinase (12)
P450 (12)
Antifungal (12)
Interleukin (12)
Casein Kinase (11)
Rho (11)
DNA/RNA Synthesis (11)
PKA (11)
Gamma-secretase (11)
ALK (10)
Nrf2 (10)
FGFR (10)
PERK (10)
NOD (10)
Dehydrogenase (9)
PDK (9)
ROCK (9)
Lipoxygenase (8)
PARP (8)
HSV (8)
c-RET (8)
Potassium Channel (8)
Beta Amyloid (8)
NO Synthase (7)
NOD-like Receptor (NLR) (7)
SARS-CoV (7)
BCL (7)
Tyrosine Kinases (7)
Ligand for E3 Ligase (7)
PDE (7)
PI4K (7)
MLK (6)
p97 (6)
IGF-1R (6)
Mitochondrial Metabolism (6)
MNK (6)
AChE (6)
RIP kinase (6)
Serine Protease (6)
Trk receptor (6)
Xanthine Oxidase (5)
NOS (5)
Cannabinoid Receptor (5)
Glucosidase (5)
Adrenergic Receptor (5)
Tyrosinase (5)
Adenosine Receptor (5)
Calcium Channel (5)
FAK (5)
P-gp (4)
ASK (4)
Sodium Channel (4)
c-Fms (4)
SGK (4)
Chk (4)
Aryl Hydrocarbon Receptor (4)
BTK (4)
Cysteine Protease (4)
HCV Protease (4)
Phosphatase (4)
TOPK (4)
Glutathione Peroxidase (4)
c-Met/HGFR (4)
HBV (4)
Wnt/beta-catenin (4)
Topoisomerase (3)
Integrin (3)
SIK (3)
AChR (3)
Drug Metabolite (3)
ROS Kinase (3)
Antiviral (3)
Carbonic Anhydrase (3)
BACE (3)
IAP (3)
Molecular Glues (3)
Epigenetic Reader Domain (3)
TRP/TRPV Channel (3)
Phospholipase (3)
PTEN (3)
GABA Receptor (3)
Estrogen/progestogen Receptor (3)
LRRK2 (3)
Syk (3)
Serine/threonin kinase (2)
MELK (2)
BMI-1 (2)
transporter (2)
HER (2)
Hck (2)
Reverse Transcriptase (2)
Aminopeptidase (2)
Estrogen Receptor/ERR (2)
MRP (2)
Aromatase (2)
GTPase (2)
KLF (2)
GPR (2)
IFNAR (2)
NADPH (2)
Histamine Receptor (2)
Leukotriene Receptor (2)
PLK (2)
Transferase (2)
PGE Synthase (2)
DNA (2)
PD-1/PD-L1 (2)
ACK (2)
Opioid Receptor (2)
AhR (2)
IRAK (2)
SGLT (2)
Microtubule Associated (2)
Proton pump (2)
Beta-Secretase (2)
CSF-1R (2)
Glucocorticoid Receptor (2)
NEDD8 (2)
TAM Receptor (2)
Prostaglandin Receptor (2)
RAAS (2)
DNA Alkylation (2)
Chloride channel (2)
S1P Receptor (1)
Kinesin (1)
ATPase (1)
Monoamine Oxidase (1)
Na+/Ca2+ Exchanger (1)
PKM (1)
Ligands for Target Protein for PROTAC (1)
CFTR (1)
LTR (1)
DNA Alkylator/Crosslinker (1)
PROTACs (1)
Gap Junction Protein (1)
Protease-activated Receptor (1)
LPL Receptor (1)
Anti-infection (1)
NADPH-oxidase (1)
YAP (1)
DNA Methyltransferase (1)
Amino Acids and Derivatives (1)
FAAH (1)
Lipase (1)
Glucagon Receptor (1)
iGluR (1)
BCRP (1)
ATP Citrate Lyase (1)
Myosin (1)
Annexin A (1)
FLAP (1)
Androgen Receptor (1)
Indoleamine 2,3-Dioxygenase (IDO) (1)
Antifection (1)
Amylase (1)
cAMP (1)
GluR (1)
Guanylate cyclase (1)
PAD (1)
Fatty Acid Synthase (1)
Thioredoxin (1)
CXCR (1)
CCR (1)
MAO (1)
PYK2 (1)
Adenosine deaminase (1)
Neprilysin (1)
Hydroxylase (1)
Tie-2 (1)
5-HT Receptor (1)
Factor Xa (1)
Progesterone Receptor (1)
c-Myc (1)
Retinoid Receptor (1)
PAK (1)
Pim (1)
STING (1)
RSV (1)
Pyroptosis (1)
cell cycle arrest (1)
PAI-1 (1)
Liver X Receptor (1)
Ephrin Receptor (1)
Free radical scavengers (1)
FXR (1)
GPX (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE