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Histamine & Melatonin Receptor-Targeted Compound Library

カタログ番号 L3300
  ライブラリー構成化合物リスト   Excel SDF

Histamine, an important bioactive molecule, is derived from the decarboxylation of the amino acid histidine. Most histamine in the body is generated in granules in mast cells and in skin, lung and gastrointestinal tract, playing a pivotal role in allergic and inflammatory reactions. Histamine acts as a neurotransmitter within the central nervous system. The histaminergic neurons that secrete histamine are localized in small regions of the hypothalamus, but those neurons send axons widely throughout the brain. Histamine appears to modulate a number of important processes in the brain, including wakefulness, cognitive ability and food consumption. Currently four histamine receptors (H1R-H4R) have been cloned and identified, all of which are G protein-coupled receptors. These different receptors are expressed on different cell types and work through different intracellular signaling mechanisms. Post mortem studies have revealed alterations in histaminergic system in neurological and psychiatric diseases.

Melatonin is a hormone, produced by the pineal gland, a tiny endocrine gland situated at the center of the brain. Melatonin presents several ways of action in the regulation of seasonal reproduction, body weight and energy balance, antiaging, and promoting sleep.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • ヒスタミン受容体およびメラトニン受容体に対して作用する153化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)による新薬創成に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済み
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L3300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Histamine Receptor (132)
5-HT Receptor (40)
Dopamine Receptor (21)
Adrenergic Receptor (19)
AChR (14)
Norepinephrine (11)
Apoptosis (9)
Autophagy (8)
Melatonin Receptor (7)
Endogenous Metabolite (6)
MT Receptor (6)
Antibacterial (6)
Calcium Channel (4)
CaMK (4)
Parasite (4)
Sodium Channel (4)
Potassium Channel (3)
P450 (3)
Histone Methyltransferase (3)
Mitophagy (2)
Serotonin Transporter (2)
Antifungal (2)
iGluR (2)
PDE (2)
Sigma receptor (2)
HCV Protease (2)
Trk receptor (2)
Opioid Receptor (2)
Influenza Virus (1)
NOS (1)
GPR (1)
NF-κB (1)
Phospholipase (1)
MEK (1)
Platelet aggregation (1)
FAK (1)
NO Synthase (1)
SARS-CoV (1)
Reactive Oxygen Species (1)
P-gp (1)
Caspase (1)
ROR (1)
p38 MAPK (1)
Estrogen/progestogen Receptor (1)
Na+/Ca2+ Exchanger (1)
Glutathione Peroxidase (1)
HBV (1)
Antifolate (1)
VEGFR (1)
ERK (1)
AChE (1)
PAFR (1)
Drug Metabolite (1)
NMDAR (1)
IL Receptor (1)
cAMP (1)
DNA (1)
Interleukin (1)
TGF-beta/Smad (1)
HER (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE