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JAK-STAT Compound Library

カタログ番号 L3700
  ライブラリー構成化合物リスト   Excel SDF

Cell signal transduction is the transmission of molecular signals via various proteins in a signaling cascade, which carries and amplifies the signal. The JAK-STAT signaling pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signaling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2, and there are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.

JAK/STAT Compound Library from TargetMol, a unique collection of 252 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • JAK/STATシグナルに関連する252種類の生物活性化合物を独自に収集したライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • JAK/STATシグナル関連研究に最適
  • 非臨床試験および臨床試験において生物活性と安全性が確認済み
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L3700)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

EGFR (97)
JAK (80)
STAT (71)
Apoptosis (60)
Autophagy (32)
HER (24)
Tyrosine Kinases (20)
FLT (13)
Src (12)
VEGFR (12)
PDGFR (9)
NF-κB (9)
CDK (9)
Pim (9)
Potassium Channel (9)
FGFR (9)
Antibacterial (8)
Parasite (7)
Endogenous Metabolite (6)
Antibiotic (5)
Bcr-Abl (4)
Somatostatin (4)
IL Receptor (4)
IκB/IKK (4)
HIV Protease (4)
c-RET (4)
p38 MAPK (4)
Histone Methyltransferase (3)
COX (3)
BTK (3)
c-Kit (3)
Ferroptosis (3)
Syk (3)
IGF-1R (3)
Interleukin (3)
ERK (3)
Influenza Virus (3)
AMPK (3)
Reactive Oxygen Species (2)
TNF (2)
MEK (2)
Akt (2)
5-HT Receptor (2)
TLR (2)
Sodium Channel (2)
Beta Amyloid (2)
Aurora Kinase (2)
Estrogen Receptor/ERR (2)
HCV Protease (2)
Virus Protease (2)
Mitophagy (2)
Caspase (2)
IFNAR (2)
PKC (2)
HIF/HIF Prolyl-Hydroxylase (1)
Histamine Receptor (1)
HDAC (1)
c-Fms (1)
NO Synthase (1)
GSK-3 (1)
Dopamine Receptor (1)
P450 (1)
HIF (1)
PLK (1)
Phosphatase (1)
JNK (1)
PD-1/PD-L1 (1)
Na+/Ca2+ Exchanger (1)
cholecystokinin (1)
FAK (1)
Antioxidant (1)
HBV (1)
AChR (1)
PI3K (1)
Antifungal (1)
Estrogen/progestogen Receptor (1)
Anti-infection (1)
Integrin (1)
NADPH-oxidase (1)
Ras (1)
PKA (1)
BCL (1)
Reverse Transcriptase (1)
TGF-beta/Smad (1)
Drug Metabolite (1)
FAAH (1)
Raf (1)
CXCR (1)
PTEN (1)
PDE (1)
Chk (1)
MMP (1)
NOS (1)
cAMP (1)
UGT (1)
Topoisomerase (1)
Adrenergic Receptor (1)
ROCK (1)
Calcium Channel (1)
ROS (1)
DNA/RNA Synthesis (1)
Survivin (1)
P-gp (1)
HSP (1)
Nucleoside Antimetabolite/Analog (1)
Trk receptor (1)
Histone Acetyltransferase (1)
Nrf2 (1)
hCE (1)
ALK (1)
Casein Kinase (1)
Cysteine Protease (1)
Wnt/beta-catenin (1)
Hippo pathway (1)
Monoamine Oxidase (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE