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Macrocyclic Compound Library

カタログ番号 L9300
  ライブラリー構成化合物リスト   Excel SDF

Macrocyclic compounds are highly significant in drug and research development. When developing new drugs, macrocyclic compound are commonly researched in the medical field. Macrocyclic compounds are becoming more successfully recognised as an approach for low drug availability targets, such as antimicrobial, antiviral, and protein-protein interactions (PPIs). Topologically, macrocyclic compounds have a unique ability to span large surface areas whilst remaining conformationally restricted when compared to acyclic molecules of equivalent molecular weight. Macrocyclic compounds also reduce the overall polarity and enhance membrane permeability. Therefore, together these attributes make macrocycles a powerful approach for any lead discovery programme against challenging targets.

Research into macrocyclic compounds is increasing and are widely used in antibacterial, antiviral, and antitumor drugs for clinical applications. On antibacterial aspects, macrolides, cyclic peptides, aza-macrocyclic compounds, etc., for example, have the characteristics of broad antibacterial spectrum antibiotics. They also exhibit strong antibacterial activity, remarkable curative effect and circumvent drug resistance.

Clinical application of anti-herpes virus drugs, like ganciclovir and cidofovir have severe side effects with poor antiviral activity. Presently, attention is focused on research of naphthyridines. Some compounds already synthesised via computer technology are already exhibiting strong anti-herpes virus activity.

On anti-tumour aspects, epothilone has a similar mechanism of action as paclitaxel. Epothilone is highly toxic to cells that have developed resistance to paclitaxel, therefore overcomes the weakness displayed by paclitaxel.

With the continuous development of chemical synthesis technology, the discovery of macrocyclic lead compounds from natural products, improvement of the availability of genomic sequences and bioinformatics have marked the arrival of times of the exploration of new macrocyclic drugs. As research progresses macrocyclic drugs are sure to have a bright application prospect.

TargetMol’s Macrocyclic Compound Library collects 210 macrocyclic compounds of known activity for the study of macrocyclic drugs.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 生物活性が報告されている210種類の大員環化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 抗菌剤、抗ウイルス薬、タンパク質間相互作用(PPI)阻害剤の研究開発に最適
  • ほとんどの化合物はFDAの承認を受けており、安全性および生物活性情報が確認済み
  • NMRとHPLCにより高純度と高品質を担保
  • ライブラリーの化合物は全て単品でのお取扱いおよび在庫をご用意

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梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L9300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Antibiotic (67)
Antibacterial (51)
Autophagy (28)
Apoptosis (25)
Microtubule Associated (14)
Antifungal (12)
Parasite (10)
Endogenous Metabolite (9)
ribosome (9)
NF-κB (7)
Integrin (7)
DNA/RNA Synthesis (7)
HIV Protease (7)
Phosphatase (5)
mTOR (5)
TNF (5)
SARS-CoV (5)
HSP (5)
HCV Protease (5)
Mitophagy (4)
HSV (4)
P-gp (4)
P450 (4)
Reactive Oxygen Species (4)
Vasopressin Receptor (4)
JAK (4)
Sodium Channel (3)
Tyrosine Kinases (3)
Antioxidant (3)
FLT (3)
ROS (3)
Oxytocin Receptor (3)
Influenza Virus (3)
Estrogen/progestogen Receptor (3)
Potassium Channel (3)
Melanocortin Receptor (3)
MMP (2)
Telomerase (2)
COX (2)
Interleukin (2)
ALK (2)
GluCls (2)
Trk receptor (2)
CXCR (2)
Somatostatin (2)
IL Receptor (2)
Complement System (2)
ATPase (2)
Guanylate cyclase (2)
ROS Kinase (2)
FAK (2)
P2X Receptor (2)
TLR (2)
Cell wall (2)
AChR (2)
TAM Receptor (1)
Platelet aggregation (1)
GABA Receptor (1)
Cannabinoid Receptor (1)
STAT (1)
AMPK (1)
IκB/IKK (1)
GST (1)
HDAC (1)
Reverse Transcriptase (1)
CRISPR/Cas9 (1)
Chloride channel (1)
Akt (1)
PKC (1)
Src (1)
Dehydrogenase (1)
YAP (1)
c-Met/HGFR (1)
PI3K (1)
Histamine Receptor (1)
JNK (1)
VDA (1)
Progesterone Receptor (1)
Virus Protease (1)
MRP (1)
HBV (1)
Estrogen Receptor/ERR (1)
Calcium Channel (1)
ERK (1)
EGFR (1)
Adrenergic Receptor (1)
Glucocorticoid Receptor (1)
Topoisomerase (1)
Bcr-Abl (1)
CDK (1)
Glucosidase (1)
Antifection (1)
BCL (1)
Endothelin Receptor (1)
PTEN (1)
Epigenetic Reader Domain (1)
CaMK (1)
Androgen Receptor (1)
TGF-beta/Smad (1)
NOD-like Receptor (NLR) (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE