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Microtubule-Targeted Compound Library

カタログ番号 L1110
  ライブラリー構成化合物リスト   Excel SDF

Microtubules (MTs) are cylindrical polymers of α- and β-tubulin heterodimers. These polymers are highly dynamic and their polymerization dynamics is tightly regulated through the binding of microtubule-associated proteins (MAPs). Microtubule polymerization and depolymerization dynamic drive chromosome congression and spindle formation during cell division, which are used to pull eukaryotic chromosomes apart. Microtubules are very important in a number of cellular processes, such as maintaining the structure of the cell, cell division, signaling transduction, transportation, etc.

Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. Microtubule-targeting anticancer drugs are among the most effective anticancer therapeutics used in the clinic today.  Microtubule-targeting agents act primarily by altering MT dynamics. This interference with microtubule dynamics can have the effect of stopping a cell's cell cycle and can lead to programmed cell death or apoptosis. They are roughly classified into microtubule-stabilizing agents, such as taxanes (paclitaxel) or epothilones. They block dynamic instability by stabilizing GDP-bound tubulin in the microtubule to inhibit the mitosis and induce apoptosis; microtubule-destabilizing agents, such as vinca alkaloids, Nocodazole, combretastatin, and colchicine. 

TargetMol’s Microtubule-targeted Compound Library collects 142 compounds targeting microtubules that can be used in microtubule-related mechanism study and drug development.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 微小管を標的とする142の生物活性化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 化合物の概要、化学構造、標的、生物活性など詳細な情報を提供
  • NMRとHPLC/LCMSにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1110)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Microtubule Associated (120)
Apoptosis (34)
Parasite (10)
Autophagy (9)
Src (4)
Antibiotic (4)
Beta Amyloid (3)
Reactive Oxygen Species (3)
HDAC (3)
NO Synthase (3)
Kinesin (3)
GSK-3 (2)
ALK (2)
Antifungal (2)
Guanylate cyclase (2)
Endogenous Metabolite (2)
Monoamine Oxidase (2)
mTOR (2)
Akt (2)
Ras (1)
FGFR (1)
HIF (1)
NF-κB (1)
CRISPR/Cas9 (1)
HIF/HIF Prolyl-Hydroxylase (1)
AChR (1)
HIV Protease (1)
Sirtuin (1)
Glucokinase (1)
PROTACs (1)
Dynamin (1)
p38 MAPK (1)
DYRK (1)
JNK (1)
GTPase (1)
ERK (1)
Hedgehog/Smoothened (1)
Topoisomerase (1)
Bcr-Abl (1)
Gamma-secretase (1)
Mitochondrial Metabolism (1)
BCL (1)
ATPase (1)
Fatty Acid Synthase (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE