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Neurotransmitter Receptor Compound Library

カタログ番号 L2610
  ライブラリー構成化合物リスト   Excel SDF

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into its corresponding receptor in the membrane, bind and trigger other events to occur inside the cell. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. Neurotransmitter (NT) receptors are located on the surface of neuronal and glial cells.

There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic means that ions can pass through the receptor, whereas metabotropic means that a second messenger inside the cell relays the message (i.e. metabotropic receptors do not have channels). Metabotropic receptors are in fact G protein-coupled receptors. Ionotropic receptors are also called Ligand-gated ion channels and they can be excited by neurotransmitters like glutamate and aspartate. There are several major classes of neurotransmitters: Adrenergic, Dopaminergic, GABAergic, Glutaminergic, Histaminergic, Cholinergic, Opioid, Serotonergic, and Glycinergic.

In the brain, most drug targets consist of signaling proteins that go awry in central nervous system diseases, for example with autism in childhood, schizophrenia in adolescence, or Alzheimer's disease in old age. The aim of drug treatment is to correct the inappropriate behavior of these proteins and restore normal brain function. Understanding the effects of neurotransmitters is extremely important in therapeutics. All psychiatric drugs act by affecting neurotransmitters. Understanding their mechanism of action and adverse effects is key to developing new drugs for neurological diseases.

The TargetMol neurotransmitter receptor compound library contains 1513 CNS receptor ligands, which is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays, and for routine pharmacological applications.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • 神経伝達物質受容体に関連する1513種類の化合物を独自に収集したライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • ターゲットには5-HT受容体、AChR、GABA受容体、ドーパミン受容体、オピオイド受容体、イオンチャネル型グルタミン酸受容体、代謝型グルタミン酸受容体、プリン受容体など
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • 化合物の概要、化学構造、標的、生物活性など詳細な情報を提供
  • NMRとHPLC/LCMSなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L2610)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

5-HT Receptor (347)
AChR (277)
Dopamine Receptor (219)
Adrenergic Receptor (212)
Histamine Receptor (152)
GABA Receptor (141)
GluR (91)
Opioid Receptor (72)
Adenosine Receptor (72)
AChE (71)
iGluR (68)
NMDAR (63)
Autophagy (56)
Endogenous Metabolite (54)
Apoptosis (40)
Norepinephrine (31)
Serotonin Transporter (28)
Antibacterial (27)
Calcium Channel (24)
Potassium Channel (23)
Parasite (19)
Sodium Channel (18)
Neuropeptide Y Receptor (17)
Endothelin Receptor (17)
P450 (15)
PDE (14)
Influenza Virus (11)
NF-κB (9)
Antibiotic (7)
cholecystokinin (7)
Antifungal (7)
HIV Protease (7)
CaMK (7)
HDAC (6)
Phospholipase (6)
Reactive Oxygen Species (6)
COX (6)
TRP/TRPV Channel (5)
P-gp (5)
TNF (5)
Mitophagy (5)
HCV Protease (5)
Monoamine Transporter (4)
Adenosine deaminase (4)
NO Synthase (4)
Histone Methyltransferase (4)
DNA/RNA Synthesis (4)
Ferroptosis (4)
MAO (4)
ERK (4)
Dehydrogenase (4)
Beta Amyloid (4)
Virus Protease (4)
Sigma receptor (4)
HSV (3)
Prostaglandin Receptor (3)
Monoamine Oxidase (3)
Chloride channel (3)
P2X Receptor (3)
Transferase (3)
Drug Metabolite (3)
Cannabinoid Receptor (3)
BACE (3)
RAAS (3)
Beta-Secretase (3)
Tyrosinase (3)
Glucocorticoid Receptor (3)
ABC (3)
GPR (3)
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Caspase (3)
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IL Receptor (2)
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NOS (2)
Transaminase (2)
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Antioxidant (2)
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MRP (2)
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MEK (2)
Anti-infection (2)
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PAFR (2)
GST (1)
Hydroxylase (1)
GluCls (1)
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p53 (1)
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HIF/HIF Prolyl-Hydroxylase (1)
Microtubule Associated (1)
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NOD (1)
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Melanin-concentrating Hormone Receptor (MCHR) (1)
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OCT (1)
Adiponectin receptor (1)
Annexin A (1)
Immunology/Inflammation related (1)
IAP (1)
Aryl Hydrocarbon Receptor (1)
PKC (1)
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Integrin (1)
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Interleukin (1)
Androgen Receptor (1)
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DNA (1)
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Mitochondrial Metabolism (1)
Glucosidase (1)
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MT Receptor (1)
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化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE