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Osteogenesis Compound Library

カタログ番号 L7900
  ライブラリー構成化合物リスト   Excel SDF

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts. The equilibrium between bone formation and resorption is necessary and depends on the action of several local and systemic factors including hormones, cytokines, chemokines, and biomechanical stimulation. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Osteoblasts are the main functional cells of bone formation and are responsible for the synthesis, secretion and mineralization of bone matrix. Osteoblasts undergo four stages of osteoblast proliferation, extracellular matrix maturation, extracellular matrix mineralization, and osteoblast apoptosis during bone formation. Many factors are involved in these stages to ultimately regulate bone formation.

Multiple signaling pathways were found to be involved in osteogenic proliferation and differentiation. Among them, BMP-SMAD, Wnt/β-Catenin, Notch, Hedgehog, MAPK, and FGF signaling pathways play the most critical roles in regulating osteogenic differentiation. Osteogenesis Compound Library from TargetMol collects 317 osteogenesis related bioactive compounds that can be used for research in bone formation and drug screening.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • HTS、HCSに適した317種の骨形成関連化合物の独自コレクション
  • BMP-SMAD、Notch、MAPK、Wnt/β-catenin、Hedgehog、FGFなどのシグナル伝達経路をカバー
  • 骨形成や骨粗鬆症、骨腫瘍などの骨関連疾患に関する研究に有効
  • 非臨床研究や臨床試験により生物活性と安全性が確認済み
  • 化学構造的の多様性、薬理作用、細胞膜透過性をもつ化合物群
  • 化合物の概要、化学構造、標的、活性、IC50値など、詳細な情報を提供

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L7900)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

p38 MAPK (72)
FGFR (71)
Wnt/beta-catenin (63)
Autophagy (61)
Apoptosis (58)
MAPK (35)
VEGFR (31)
ERK (27)
PDGFR (26)
Hedgehog/Smoothened (24)
Src (17)
JNK (16)
NF-κB (15)
c-Kit (13)
Smo (12)
FLT (11)
PARP (10)
Endogenous Metabolite (10)
CDK (9)
Aurora Kinase (9)
TGF-beta/Smad (7)
Akt (7)
JAK (7)
Caspase (7)
Casein Kinase (7)
Antibacterial (7)
Antifungal (7)
EGFR (7)
STAT (6)
c-RET (6)
Bcr-Abl (6)
PERK (6)
Raf (6)
IGF-1R (5)
MEK (5)
COX (5)
Reactive Oxygen Species (5)
c-Fms (5)
ALK (5)
Parasite (5)
PKC (5)
S6 Kinase (5)
TNF (4)
GSK-3 (4)
Porcupine (4)
ASK (4)
c-Met/HGFR (4)
BCL (4)
DNA/RNA Synthesis (3)
Ferroptosis (3)
FAK (3)
Antibiotic (3)
Phosphatase (3)
IL Receptor (3)
AMPK (3)
P450 (3)
PKA (3)
Topoisomerase (2)
Tie-2 (2)
HER (2)
IκB/IKK (2)
AChE (2)
Antioxidant (2)
Influenza Virus (2)
NO Synthase (2)
Serine Protease (2)
Calcium Channel (2)
Carbonic Anhydrase (2)
MMP (2)
Chk (2)
5-HT Receptor (2)
Trk receptor (2)
SGK (1)
Methionine Adenosyltransferase (MAT) (1)
MELK (1)
GABA Receptor (1)
AhR (1)
AChR (1)
Discoidin Domain Receptor (DDR) (1)
Ras (1)
Syk (1)
Microtubule Associated (1)
TAM Receptor (1)
Aromatase (1)
Sodium Channel (1)
PLK (1)
NOD (1)
Beta Amyloid (1)
HIV Protease (1)
TSH Receptor (1)
ABC (1)
TRP/TRPV Channel (1)
Hck (1)
Rho (1)
PPAR (1)
Tyrosine Kinases (1)
Estrogen Receptor/ERR (1)
HBV (1)
Virus Protease (1)
CSF-1R (1)
Mitophagy (1)
Histamine Receptor (1)
Lipase (1)
Adenosine Receptor (1)
PI3K (1)
Arginase (1)
Estrogen/progestogen Receptor (1)
DHFR (1)
Aryl Hydrocarbon Receptor (1)
Phosphorylase (1)
transporter (1)
DNA (1)
TLR (1)
Antiviral (1)
P-gp (1)
MNK (1)
mTOR (1)
Androgen Receptor (1)
CaMK (1)
Epigenetic Reader Domain (1)
Glucosidase (1)
Lipoxygenase (1)
ATPase (1)
ACK (1)
HSV (1)
DNA Alkylation (1)
MAGL (1)
Guanylate cyclase (1)
Antifection (1)
Kinesin (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE