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Potassium Channel Blocker Library

カタログ番号 L7300
  ライブラリー構成化合物リスト   Excel SDF

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore, potassium channels are found in most cell types and control a wide variety of cell functions, such as regulation of cellular excitability, neurotransmitter release, protecting cardiac myocytes, and anti-arrhythmia function, and are involved in learning and memory process, and temperature control. Potassium channel blockers is a class of drugs that act by inhibition of potassium efflux through cell membranes, including inorganic ions (Cs, Ba) and organic molecules (TEA, 4-AP), toxins (scorpion venoms, snake venoms, and bee venoms), and potassium channel blockers in clinical use.

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • カリウムチャネル遮断薬または促進剤である152種類の生物活性化合物を独自に収集したライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • ターゲットにはカリウムチャネルのサブタイプKir1.1、Kir3.x、Kir6.xおよびKv7.1など
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、一部に承認薬を含む
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • 一部にFDA承認薬有効成分を含む
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L7300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Potassium Channel (152)
Autophagy (22)
Sodium Channel (16)
Calcium Channel (10)
HER (7)
5-HT Receptor (7)
Parasite (7)
Adrenergic Receptor (7)
AChR (6)
Apoptosis (5)
ATPase (5)
Antibacterial (5)
EGFR (4)
COX (4)
P450 (4)
Dopamine Receptor (4)
MRP (3)
ABC (3)
iGluR (3)
Antibiotic (3)
Endogenous Metabolite (3)
PPAR (3)
AMPK (2)
NF-κB (2)
TNF (2)
Reactive Oxygen Species (2)
Drug Metabolite (2)
GPR (2)
Chloride channel (2)
Antifungal (2)
Carbonic Anhydrase (2)
TRP/TRPV Channel (2)
Topoisomerase (2)
NADPH (2)
Histamine Receptor (2)
NMDAR (2)
NO Synthase (1)
Integrin (1)
Proteasome (1)
HMG-CoA Reductase (1)
NOD-like Receptor (NLR) (1)
GSK-3 (1)
Thrombin (1)
CFTR (1)
PAI-1 (1)
Platelet aggregation (1)
STAT (1)
JNK (1)
Na+/Ca2+ Exchanger (1)
GABA Receptor (1)
NOD (1)
Estrogen/progestogen Receptor (1)
Gap Junction Protein (1)
Mitochondrial Metabolism (1)
Beta Amyloid (1)
Estrogen Receptor/ERR (1)
CaMK (1)
FXR (1)
PKC (1)
ERK (1)
Antifection (1)
Monoamine Transporter (1)
LDL (1)
NOS (1)
CXCR (1)
GluR (1)
DNA (1)
VEGFR (1)
PDE (1)
BCRP (1)
DNA/RNA Synthesis (1)
P-gp (1)
SARS-CoV (1)
mTOR (1)
Caspase (1)
IκB/IKK (1)
DNA gyrase (1)
IL Receptor (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE