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Protease Inhibitor Library

カタログ番号 L1100
  ライブラリー構成化合物リスト   Excel SDF

Protease inhibitors are molecules that inhibit the function of proteases (enzymes that aid the breakdown of proteins), including proteins protease inhibitors, natural protease inhibitors, and synthetic protease inhibitors. (1). Antiprotozoal activity: protease inhibitors could be used against malaria and gastrointestinal protozoal infections; (2). Antiretrovirals: protease inhibitors were the second class of antiretroviral drugs developed widely used to treat HIV/AIDS and hepatitis C; (3). Anticancer activity: Researchers are investigating whether protease inhibitors could possibly be used to treat cancer. For example, nelfinavir and atazanavir are able to kill tumor cells in culture. Inhibitors of the proteasome, such as bortezomib are now front-line drugs for the treatment of multiple myeloma. Marimastat and batimastat are two of the matrix metalloproteinase inhibitors that can be used to treat cancer.

The Protease Inhibitor Library by TargetMol, containing 343 small protease and proteasome inhibitors, can be used for research in Chemical Genomics and drug screening.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。 また、個人の方への販売は行っておりません。
パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
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製品概要

  • プロテアーゼおよびプロテアソーム阻害活性を有する343種類の生物活性化合物を独自に収集したライブラリーで、化学ゲノミクスおよび創薬におけるスクリーニングに最適
  • ターゲットにはプロテアソーム、DPP-4、セリンプロテアーゼ、システインプロテアーゼ、MMP、アスパラギン酸プロテアーゼなど
  • 非臨床試験および臨床試験において生物活性と安全性が確認済みで、一部に承認薬を含む
  • 化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • 一部にFDA承認薬有効成分を含む
  • NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L1100)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

MMP (57)
Proteasome (48)
Tyrosinase (48)
Caspase (47)
Apoptosis (44)
Autophagy (30)
Gamma-secretase (29)
HIV Protease (29)
Cysteine Protease (28)
SARS-CoV (24)
Serine Protease (24)
DPP-4 (23)
Antibacterial (20)
Thrombin (17)
HCV Protease (14)
Endogenous Metabolite (12)
NF-κB (11)
BCL (9)
COX (8)
Parasite (8)
PARP (8)
Beta Amyloid (8)
p38 MAPK (8)
TNF (7)
Serine/threonin kinase (7)
Akt (6)
ERK (6)
Virus Protease (6)
PPAR (6)
BACE (5)
P450 (5)
Glutaminase (5)
Factor Xa (4)
P-gp (4)
Antifungal (4)
Beta-Secretase (4)
VEGFR (4)
Ferroptosis (4)
Reactive Oxygen Species (4)
Influenza Virus (4)
Antibiotic (4)
AMPK (4)
GABA Receptor (4)
DUB (3)
transporter (3)
Lipoxygenase (3)
HDAC (3)
Interleukin (3)
Prostaglandin Receptor (3)
AChR (3)
HSV (3)
IL Receptor (3)
Antioxidant (3)
JNK (3)
Mitophagy (3)
Histamine Receptor (3)
Anti-infection (3)
IAP (2)
NO Synthase (2)
Sodium Channel (2)
ribosome (2)
5-HT Receptor (2)
Immunology/Inflammation related (2)
PAI-1 (2)
Free radical scavengers (2)
Platelet aggregation (2)
Potassium Channel (2)
Estrogen/progestogen Receptor (2)
CDK (2)
Drug Metabolite (2)
PI3K (2)
Phosphatase (2)
STAT (1)
c-Kit (1)
p53 (1)
Protease (1)
Microtubule Associated (1)
Phospholipase (1)
Ras (1)
Aurora Kinase (1)
IκB/IKK (1)
UGT (1)
ATPase (1)
Proton pump (1)
ROR (1)
Src (1)
Amino Acids and Derivatives (1)
Na+/Ca2+ Exchanger (1)
Tyrosine Kinases (1)
Calcium Channel (1)
PKC (1)
Adrenergic Receptor (1)
Topoisomerase (1)
E1/E2/E3 Enzyme (1)
Glucosidase (1)
ALK (1)
PDGFR (1)
JAK (1)
CXCR (1)
IGF-1R (1)
DNA (1)
CaMK (1)
EGFR (1)
MAPK (1)
Antiviral (1)
TLR (1)
Sirtuin (1)
Pyroptosis (1)
HER (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE