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Wnt/Hedgehog/Notch Compound Library

カタログ番号 L4300
  ライブラリー構成化合物リスト   Excel SDF

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. Constitutive activation of the Hh pathway leading to tumorigenesis is seen in basal cell carcinomas and medulloblastoma. A variety of other human cancers, including brain, gastrointestinal, lung, breast and prostate cancers, also demonstrate inappropriate activation of this pathway. Targeting the Hh signaling pathway provides a new and exciting therapeutic option for a broad variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. The Notch signaling cascade is critical for cell proliferation, differentiation, development and homeostasis. Deregulated Notch signaling is found in various diseases, such as T-cell leukemia, breast cancer, prostate cancer, colorectal cancer and lung cancer as well as central nervous system (CNS) malignancies, CADASIL, Alagille syndrome, spondylocostal dysostosis, etc.

Wnt/Hedgehog/Notch Compound Library from TargetMol, a unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds, can be used for research in Wnt/Hedgehog/Notch signaling and related drug screening (high throughput and high content screening).

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]
ライブラリ構成化合物リストを依頼する
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製品概要

  • Wnt/Hedgehog/Notchを標的とする237化合物を収集した独自のライブラリーで、ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
  • 化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
  • 構造的多様性、薬効、細胞膜透過性を有する化合物
  • NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

  • バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
  • ブルーアイス同梱にて出荷
ライブラリ構成化合物複合リストをリクエスト (L4300)

Publications Cited TargetMol Libraries

隠し

ライブラリーの構成

Wnt/beta-catenin (62)
GSK-3 (45)
Autophagy (34)
Apoptosis (33)
Casein Kinase (28)
Hedgehog/Smoothened (25)
Gamma-secretase (22)
CDK (19)
Smo (18)
ROCK (15)
c-Myc (13)
CaMK (11)
Endogenous Metabolite (8)
PARP (7)
PKC (7)
PKA (6)
Src (6)
Antifungal (6)
NF-κB (6)
Antibacterial (5)
Porcupine (5)
Reactive Oxygen Species (5)
Beta Amyloid (4)
HIV Protease (4)
Parasite (4)
PI3K (4)
Phospholipase (4)
Aurora Kinase (3)
Mitophagy (3)
Lipoxygenase (3)
S6 Kinase (3)
Calcium Channel (3)
MEK (3)
p38 MAPK (3)
Carbonic Anhydrase (2)
Drug Metabolite (2)
COX (2)
Immunology/Inflammation related (2)
ERK (2)
Epigenetic Reader Domain (2)
Antibiotic (2)
SGK (2)
STAT (2)
Estrogen/progestogen Receptor (2)
Sodium Channel (2)
Syk (2)
JNK (2)
GABA Receptor (2)
HDAC (2)
Ferroptosis (2)
ATPase (2)
Estrogen Receptor/ERR (2)
FLT (2)
MLK (2)
JAK (2)
PI4K (1)
IGF-1R (1)
FAK (1)
HIF/HIF Prolyl-Hydroxylase (1)
Microtubule Associated (1)
MAPK (1)
Antiviral (1)
Potassium Channel (1)
MELK (1)
KLF (1)
P450 (1)
Trk receptor (1)
NO Synthase (1)
Methionine Adenosyltransferase (MAT) (1)
Influenza Virus (1)
FGFR (1)
ALK (1)
cholecystokinin (1)
HSV (1)
PDGFR (1)
ABC (1)
Topoisomerase (1)
Glucocorticoid Receptor (1)
VEGFR (1)
Serine/threonin kinase (1)
Virus Protease (1)
Dehydrogenase (1)
Proton pump (1)
Phosphatase (1)
Bcr-Abl (1)
Histamine Receptor (1)
DYRK (1)
c-Met/HGFR (1)
Arginase (1)
DNA-PK (1)
Histone Methyltransferase (1)
DHFR (1)
RIP kinase (1)
PDE (1)
LRRK2 (1)
CXCR (1)
SARS-CoV (1)
Akt (1)
TGF-beta/Smad (1)
DNA (1)
GluR (1)
MMP (1)
Chk (1)
DNA Alkylation (1)
Raf (1)
BCL (1)
Glucosidase (1)
P2X Receptor (1)
GRK (1)
Pim (1)
PPAR (1)
Tyrosine Kinases (1)
Kinesin (1)

化合物ライブラリー情報実例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE