Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) protein.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約5 days | ¥ 7,500 |
10 mg | 約5 days | ¥ 10,000 |
25 mg | 約5 days | ¥ 16,000 |
50 mg | 約5 days | ¥ 22,500 |
100 mg | 約5 days | ¥ 33,000 |
説明 | (S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) protein. |
別名 | VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) |
分子量 | 517.51 |
分子式 | C23H34Cl2N4O3S |
CAS No. | T13671L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (193.23 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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(S,R,S)-AHPC-Me dihydrochloride T13671L Others 1948273-02-6 free base VHL ligand 2 dihydrochloride 1948273-02-6 E3 ligase Ligand 1 dihydrochloride E3 ligase Ligand 1 (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) AHPC-Me Dihydrochloride E3 ligase Ligand 1 Dihydrochloride (S,R,S)AHPCMe dihydrochloride VHL ligand 2 AHPC-Me VHL ligand 2 Dihydrochloride (S,R,S) AHPC Me dihydrochloride Inhibitor inhibitor inhibit