Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 18,000 |
5 mg | 約 35 days | ¥ 66,500 |
10 mg | 約 35 days | ¥ 123,000 |
25 mg | 約 35 days | ¥ 262,000 |
説明 | (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis. |
分子量 | 258.75 |
分子式 | C15H15ClN2 |
CAS No. | 1000672-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 20 mg/mL
DMSO: 2 mg/mL
Ethanol: 2 mg/mL
DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
You can also refer to dose conversion for different animals. 詳細
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(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine 1000672-89-8 (E)2(2Chlorostyryl)3,5,6trimethylpyrazine (E) 2 (2 Chlorostyryl) 3,5,6 trimethylpyrazine 2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine Inhibitor inhibitor inhibit