Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1]. |
In vivo | α-Glucosidase-IN-16 (compound 13B), administered orally at doses of 10 and 20 mg/kg once daily for 28 days, significantly reduces blood glucose levels in diabetic Wistar rats (170-200 g, 8-10 weeks old) induced by intraperitoneal injection of Streptozotocin, without exhibiting toxicity at a single dose of 2000 mg/kg in Balb/C mice. This compound also effectively lowers serum glucose levels in rats to 110-113 mg/dL compared to a control level of 128 mg/dL after a single oral dosage following glucose administration. Over the 28-day period, a consistent reduction in blood glucose levels was observed, reaching 132.98 ± 4.33 mg/dL and 108.42 ± 3.98 mg/dL for the 10 and 20 mg/kg doses, respectively. Additionally, α-Glucosidase-IN-16 was noted to reduce total cholesterol levels, indicating its potential benefits for diabetic and hypercholesterolemic conditions. |
分子量 | 347.45 |
分子式 | C22H18FNS |
CAS No. | 1606142-34-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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α-Glucosidase-IN-16 1606142-34-0 Inhibitor inhibitor inhibit