Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1]. |
In vivo | In a study, α-Glucosidase-IN-18 (7B) administered orally at doses of 10 or 20 mg/kg exhibited antidiabetic properties by significantly lowering blood glucose levels from 392.16 mg/dL in diabetic controls to 112.97 mg/dL at the 20 mg/kg dose after 28 days in male Wistar albino rats with streptozotocin-induced diabetes. This compound also mitigated diabetes-induced weight loss. Additionally, it demonstrated anti-hyperlipidemic effects, reducing total cholesterol levels from 226.03 mg/dL to 136.4 mg/dL, LDL from 183.3 mg/dL to 114.18 mg/dL, and triglycerides from 189.35 mg/dL to 118.61 mg/dL. Furthermore, α-Glucosidase-IN-18 (7B) decreased ALP, SGPT, and SGOT levels, improved renal function by reducing serum creatinine from 3.01 mg/dL to as low as 0.79 mg/dL, and increased insulin levels from 0.369 mg/dL to 0.639 mg/dL, indicating a potential therapeutic effect on various biochemical parameters associated with diabetes [1]. |
分子量 | 373.47 |
分子式 | C23H19NO2S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
α-Glucosidase-IN-18 Inhibitor inhibitor inhibit