Powder: -20°C for 3 years | In solvent: -80°C for 1 year
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 95,000 |
50 μg | 約 35 days | ¥ 180,000 |
100 μg | 約 35 days | ¥ 340,000 |
説明 | 11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum as a cysteinyl leukotriene receptor preparation, the pKis for LTC4 and 11-trans LTC4 were determined to be 6.42 and 6.58, respectively. |
別名 | 11-trans Leukotriene C4 |
分子量 | 625.78 |
分子式 | C30H47N3O9S |
CAS No. | 74841-69-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: >50 mg/mL (per Ramki Iyer)
PBS (pH 7.2): >100 μg/mL (per Ramki Iyer)
Ethanol: >50 mg/mL (per Ramki Iyer)
DMF: >50 mg/mL (per Ramki Iyer)
You can also refer to dose conversion for different animals. 詳細
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11-trans Leukotriene C4 74841-69-3 11trans Leukotriene C4 11-trans Leukotriene C-4 11 trans Leukotriene C4 Inhibitor inhibitor inhibit