Powder: -20°C for 3 years | In solvent: -80°C for 1 year
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 75,500 |
50 μg | 約 35 days | ¥ 141,500 |
100 μg | 約 35 days | ¥ 266,500 |
250 μg | 約 35 days | ¥ 590,000 |
説明 | 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. |
分子量 | 336.47 |
分子式 | C20H32O4 |
CAS No. | 71774-10-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Miscible
PBS (pH 7.2): 0.8 mg/mL
DMSO: Miscible
0.1 M Na2CO3: 2 mg/mL
Ethanol: Miscible
You can also refer to dose conversion for different animals. 詳細
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12(S)-HpETE 71774-10-2 12HpETE 12(S)HpETE 12(S) HpETE Inhibitor inhibitor inhibit