Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 79,500 |
50 μg | 約 35 days | ¥ 150,000 |
100 μg | 約 35 days | ¥ 280,000 |
説明 | Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM. |
別名 | 14,15-dehydro Leukotriene B4 |
分子量 | 334.45 |
分子式 | C20H30O4 |
CAS No. | 114616-11-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): >1 mg/mL
DMF: Miscible
DMSO: Miscible
Ethanol: Miscible
You can also refer to dose conversion for different animals. 詳細
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14,15-dehydro Leukotriene B4 114616-11-4 14,15 dehydro Leukotriene B4 14,15-dehydro Leukotriene B-4 14,15dehydro Leukotriene B4 Inhibitor inhibitor inhibit