Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 76,000 |
50 μg | 約 35 days | ¥ 143,000 |
100 μg | 約 35 days | ¥ 268,500 |
説明 | Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine. |
別名 | 14,15-Leukotriene E4 |
分子量 | 439.61 |
分子式 | C23H37NO5S |
CAS No. | 1000852-57-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: > 50 mg/mL
DMF: > 50 mg/mL
DMSO: > 50 mg/mL
PBS (pH 7.2): > 100μg/mL
You can also refer to dose conversion for different animals. 詳細
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14,15-Leukotriene E4 1000852-57-2 14,15Leukotriene E4 14,15 Leukotriene E4 14,15-Leukotriene E-4 Inhibitor inhibitor inhibit