Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5]
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 113,000 |
50 μg | 約 35 days | ¥ 219,500 |
100 μg | 約 35 days | ¥ 413,500 |
250 μg | 約 35 days | ¥ 900,000 |
説明 | Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.[4] 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.[5] |
別名 | 15(R)-Lipoxin A4, AT-Lipoxin A4 |
分子量 | 352.47 |
分子式 | C20H32O5 |
CAS No. | 171030-11-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 50 mg/mL
Ethanol: 50 mg/mL
PBS (pH 7.2): 1 mg/mL
You can also refer to dose conversion for different animals. 詳細
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15(R)-Lipoxin A4 171030-11-8 15Lipoxin A4 15(R)Lipoxin A4 AT-Lipoxin A4 15(R) Lipoxin A4 15(R)-Lipoxin A-4 Inhibitor inhibitor inhibit