Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 37,000 |
5 mg | 約 35 days | ¥ 157,500 |
10 mg | 約 35 days | ¥ 284,500 |
説明 | Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye. |
別名 | 15-keto-17-phenyl trinor Prostaglandin F2α |
分子量 | 386.488 |
分子式 | C23H30O5 |
CAS No. | 949564-89-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 2.5 mg/mL
DMF: 30 mg/mL
DMSO: 25 mg/mL
Ethanol: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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15-keto-17-phenyl trinor Prostaglandin F2α 949564-89-0 15-keto-17-phenyl trinor Prostaglandin F2a 15 keto 17 phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F-2α 15keto17phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F2alpha Inhibitor inhibitor inhibit