Powder: -20°C for 3 years | In solvent: -80°C for 1 year
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 μg | 約 35 days | ¥ 95,000 |
50 μg | 約 35 days | ¥ 178,500 |
100 μg | 約 35 days | ¥ 335,000 |
説明 | 20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist. |
別名 | 20-hydroxy Leukotriene B4 |
分子量 | 352.471 |
分子式 | C20H32O5 |
CAS No. | 79516-82-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: >50 mg/mL (per Rao Maddipati)
DMF: >50 mg/mL (per Rao Maddipati)
DMSO: >50 mg/mL (per Rao Maddipati)
PBS (pH 7.2): >1 mg/mL (from 13(S)-HODE)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
20-hydroxy Leukotriene B4 79516-82-8 20-hydroxy Leukotriene B-4 20hydroxy Leukotriene B4 20 hydroxy Leukotriene B4 Inhibitor inhibitor inhibit