Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered by prostaglandin E2 (PGE2), in a concentration-dependent manner within isolated human platelet-rich plasma. Additionally, this compound facilitates the relaxation of precontracted isolated guinea pig taenia coli strips (pD2 = 6.74) and reduces arterial blood pressure in rats. Moreover, 2-Chloroadenosine-5'-O-diphosphate significantly inhibits the ATPase activity of mortalin, a member of the heat shock protein 70 (Hsp70) family, with an apparent Ki of 45.05 µM for the human enzyme.
説明 | 2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered by prostaglandin E2 (PGE2), in a concentration-dependent manner within isolated human platelet-rich plasma. Additionally, this compound facilitates the relaxation of precontracted isolated guinea pig taenia coli strips (pD2 = 6.74) and reduces arterial blood pressure in rats. Moreover, 2-Chloroadenosine-5'-O-diphosphate significantly inhibits the ATPase activity of mortalin, a member of the heat shock protein 70 (Hsp70) family, with an apparent Ki of 45.05 µM for the human enzyme. |
別名 | 2-chloro ADP |
分子量 | 527.59 |
分子式 | C10H11ClN5O10P2.3Na |
CAS No. | 82927-78-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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2-Chloroadenosine-5'-O-diphosphate sodium 82927-78-4 2-chloro ADP Inhibitor inhibitor inhibit