store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 23,000 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 303,000 | |||
100 mg | 在庫あり | ¥ 489,000 |
説明 | 4A3-SC8 is a modular dendritic macromolecule with cationic and lipophilic groups that enables small RNAs to prolong survival in an aggressive hepatocellular carcinoma model and can be used to synthesize lipid nanoparticles. |
In vitro | 4A3-SC8 (100 mg/kg) is a biodegradable dendrimer with low toxicity and high delivery efficiency in mice carrying invasive liver cancer[1]. |
In vivo | After intravenous injection of 1 mg/kg siRNA, 4A3-SC8 mediated the primary accumulation of siRNA in the liver, with lesser amounts in the spleen and kidneys, and resulted in greater than 95% knockdown of FVII in mice [1]. Following administration of 4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once), the mice exhibited illness and a significant weight loss of nearly 20% on the first day post injection [1]. |
別名 | 4A3 SC8, 4A3SC8 |
分子量 | 1467.177 |
分子式 | C75H139N3O16S4 |
CAS No. | 1857340-78-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (54.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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4A3-SC8 1857340-78-3 Metabolism Liposome 4A3 SC8 4A3SC8 Inhibitor inhibitor inhibit