Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is
In vitro | 7α-Hydroxy-4-cholesten-3-one plays a crucial role early in the bile acid synthesis pathway. Initially, cytochrome P450 7A1 facilitates the introduction of a 7α-hydroxy group to cholesterol. Subsequently, a 3β-hydroxysteroid dehydrogenase mediates the oxidation and isomerization of the 3-hydroxy group along with the Δ5,6-double bond, resulting in the formation of 7α-Hydroxy-4-cholesten-3-one. Remarkably, the absence of P450 27A1, which functions downstream in this pathway, leads to an increased concentration of 7α-Hydroxy-4-cholesten-3-one [1]. |
In vivo | 7α-Hydroxy-4-cholesten-3-one significantly influences the activity of the hepatic enzyme CYP7A1, both under steady-state conditions and throughout the rapid diurnal fluctuations observed in rats. Furthermore, serum levels of 7α-Hydroxy-4-cholesten-3-one exhibit a marked diurnal rhythm. |
分子量 | 400.64 |
分子式 | C27H44O2 |
CAS No. | 3862-25-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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7α-Hydroxy-4-cholesten-3-one 3862-25-7 Others 7α Hydroxy 4 cholesten 3 one 7a-Hydroxy-4-cholesten-3-one 7alpha-Hydroxy-4-cholesten-3-one 7αHydroxy4cholesten3one Inhibitor inhibitor inhibit