Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 33,000 |
5 mg | 約 35 days | ¥ 143,000 |
10 mg | 約 35 days | ¥ 250,500 |
説明 | 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. |
分子量 | 278.436 |
分子式 | C18H30O2 |
CAS No. | 506-23-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30 mg/mL
Ethanol:PBS (pH 7.2)(1:10): 0.5 mg/mL
DMSO: 30 mg/mL
DMF: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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9(Z),11(E),13(E)-Octadecatrienoic Acid 506-23-0 9,11,13Octadecatrienoic Acid 9(Z),11(E),13(E)Octadecatrienoic Acid 9(Z),11(E),13(E) Octadecatrienoic Acid Inhibitor inhibitor inhibit