Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal. It inhibits photoreceptor degeneration and restores retinal function in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
In vitro | 9-cis-β-Carotene (1 μM; 18 hours), combined with Miglyol 810 and an antioxidant mix, is applied to eye cups derived from RPE65rd12 mice, with the neuro-retina still attached to the RPE tissue underneath. This treatment effectively prevents degeneration of S- and M-cones, resulting in more than a 2- and 9-fold increase in m-opsin and s-opsin positive staining, respectively, compared to the control group. |
In vivo | In a mouse model exhibiting defects in the retinoid cycle, specifically the RPE65rd12 mutation, administration of an extract from Dunaliella Bardawil algae, which is rich in 9-cis-β-Carotene (9CBC), via oral route, has been shown to rescue retinal function and preserve cone structure. |
分子量 | 536.87 |
分子式 | C40H56 |
CAS No. | 13312-52-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
9-cis-β-Carotene 13312-52-2 Others 9-cis-b-Carotene 9-cis-beta-Carotene 9cisβCarotene 9 cis β Carotene Inhibitor inhibitor inhibit