Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
ターゲット&IC50 | FLT3:0.6 nM (kd), c-Kit:1 nM (kd), PDGFRβ:1 nM (kd), PDGFRα:1.3 nM (kd), CSF1R:1.57 nM (kd) |
In vivo | At a dosage of 0.3 mg/kg, AC710 temporarily inhibits tumor growth, which then quickly resumes. However, at dosages of 3 and 30 mg/kg, AC710 induces complete tumor regression, with the reduction in tumor volume remaining for an extended period post-treatment cessation. Furthermore, no loss of body weight is observed in AC710-treated animals across all dosages, suggesting good tolerability in mice. Efficacy of AC710 is also noted in a mouse collagen-induced arthritis (CIA) model, showing significant disease impact in a dose-dependent manner, with noticeable effects starting from a dosage as low as 3 mg/kg over a 15-day period (day 0-14). At higher doses (10 and 30 mg/kg), AC710 is as effective, if not more so, than dexamethasone in reducing joint swelling and inflammation when administered at a safe dose. |
分子量 | 658.81 |
分子式 | C32H46N6O7S |
CAS No. | 1351522-05-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AC710 Mesylate 1351522-05-8 Angiogenesis Tyrosine Kinase/Adaptors PDGFR AC-710 Mesylate AC 710 Mesylate Inhibitor inhibitor inhibit