Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
ターゲット&IC50 | HCV:(EC50)14 nM |
In vitro | ACH-806, an NS4A antagonist, effectively hinders the replication of the Hepatitis C Virus (HCV) with an EC50 value of 14 nM. Treatment with ACH-806 notably decreases the immunoprecipitation levels of labeled NS3 and NS4A by anti-NS3 antibody. It significantly reduces NS3 and NS4A levels and facilitates p14 formation in original replicon cells, albeit not affecting ACH-806-resistant cells[1]. Moreover, ACH-806 administration leads to notable reductions in NS3 and NS4A within transfected cells, mirroring effects observed in replicon cells treated with the compound, where both NS3 and NS4A levels decrease significantly. Following ACH-806 treatment, NS3 amounts are diminished approximately 6-fold (100/16), and NS4A-bound NS3 is reduced roughly 29-fold (261/9). |
別名 | GS9132 |
分子量 | 411.44 |
分子式 | C19H20F3N3O2S |
CAS No. | 870142-71-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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ACH-806 870142-71-5 Microbiology/Virology Proteases/Proteasome HCV Protease GS9132 GS 9132 ACH806 GS-9132 ACH 806 Inhibitor inhibitor inhibit