Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme). |
ターゲット&IC50 | ROS1:0.530 μM , ALK:0.174 μM |
In vitro | ALK/ROS1-IN-1 (compound 2e) displays potent anti-proliferative activity against ALK-addicted H3122 (IC50: 6.27 μM) and ROS1-addicted HCC78 cell lines (IC50: 10.71 μM). ALK/ROS1-IN-1 shows impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M (IC50: 41.3 nM). ALK/ROS1-IN-1 shows potent inhibitory activity in Ba/F3 cell line expressing ROS1 mutants (IC50s: 137.7, 104.7 nM, and 233.9 for wide-type, G2032R mutant and L2026M mutant). ALK/ROS1-IN-1 has no significant effect on inducing apoptosis of the HCC78 cell line. |
分子量 | 584.63 |
分子式 | C30H35F3N6O3 |
CAS No. | 2365497-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ALK/ROS1-IN-1 2365497-07-8 Others ALK/ROS-1-IN-1 ALK/ROS1 IN 1 ALK/ROS1IN1 Inhibitor inhibitor inhibit