Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 19,000 |
5 mg | 約 35 days | ¥ 37,500 |
10 mg | 約 35 days | ¥ 64,500 |
25 mg | 約 35 days | ¥ 136,500 |
説明 | ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively. |
In vitro | In vitro: ALK5 inhibitor II was identified as a cell-permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5. ALK5 inhibitor II showed less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. In addition, when cocrystallized with ALK5, ALK5 inhibitor II was found to be able to bind in the ATP site with the 1,5-naphthyridine N5 interacting with the backbone NH of His-283 [1]. |
分子量 | 323.8 |
分子式 | C17H13N5·HCl |
CAS No. | 2319939-07-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤0.5mg/ml
You can also refer to dose conversion for different animals. 詳細
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ALK5 Inhibitor II (hydrochloride) 2319939-07-4 Others ALK5 Inhibitor II ALK-5 Inhibitor II (hydrochloride) Inhibitor inhibitor inhibit