Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
説明 | ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. |
In vitro | Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins.?Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively.?Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs)[1]. |
In vivo | Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases[2]. |
動物実験 | Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1]. |
植物由来 |
分子量 | N/A |
CAS No. | 8015-61-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (119.51 mM)
You can also refer to dose conversion for different animals. 詳細
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Aloin(mixture of A&B) 8015-61-0 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome Antibacterial MMP IL Receptor Antifungal inhibit Matrix metalloproteinases Bacterial Inhibitor Fungal inhibitor