Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC
ターゲット&IC50 | HIV-2 (ROD):12.3 nM (in MT-4 cells), X4 HIV-1 (HE):9.8 nM (in MT-4 cells), X4 HIV-1 (RF):7.4 nM (in MT-4 cells), X4 HIV-1 (IIIB):12.3 nM (in MT-4 cells), 12G5 mAb-CXCR4:0.75 nM (in SupT1 cells), CXCL12 (AF647)-CXCR4:18 nM (in SupT1 cells), X4 HIV-1 (NL4.3):6.1 nM (in MT-4 cells), X4 HIV-1 (NL4.3AMD3100):2822 nM (in MT-4 cells), HIV-2 (EHO):12.3 nM (in MT-4 cells) |
In vivo | AMD 3465, administered subcutaneously at a dosage of 2.5 mg/kg/day for five weeks, significantly inhibits the growth of U87 glioblastoma multiforme (GBM) and Daoy xenograft tumors. |
別名 | GENZ-644494 |
分子量 | 410.6 |
分子式 | C24H38N6 |
CAS No. | 185991-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AMD 3465 185991-24-6 Microbiology/Virology Proteases/Proteasome HIV Protease AMD3465 GENZ 644494 GENZ644494 AMD-3465 GENZ-644494 Inhibitor inhibitor inhibit